The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats

Detalhes bibliográficos
Autor(a) principal: Morais, Janaína Pereira
Data de Publicação: 2013
Outros Autores: Pereira, Denyson Santana, Matos, Alexandre Santos, Santana, Danielle Gomes, Santos, Cliomar Alves dos, Estevam, Charles dos Santos, Fakhouri, Ricardo, De Lucca Junior, Waldecy, Camargo, Enilton Aparecido
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/jspui/handle/riufs/23841
Resumo: New York
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spelling Morais, Janaína PereiraPereira, Denyson SantanaMatos, Alexandre SantosSantana, Danielle GomesSantos, Cliomar Alves dosEstevam, Charles dos SantosFakhouri, RicardoDe Lucca Junior, WaldecyCamargo, Enilton Aparecido2025-11-12T19:02:49Z2025-11-12T19:02:49Z2013MORAIS, J. P. et al. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats. The Scientific World Journal, New York, n. 1, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2013/694010. Acesso em: 12 nov. 2025.1537-744Xhttps://ri.ufs.br/jspui/handle/riufs/23841Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)engHindawi Publishing CorporationThe Scientific World JournalHemorrhagic cystitisCyclophosphamide therapyEthanol extractCaesalpinia pyramidalisThe ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNew YorkHemorrhagic cystitis (HC) is a common side effect of cyclophosphamide therapy, which deserves new therapeutic strategies, such as those based on natural products. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) (EECp) possesses anti-inflammatory, antinociceptive, and antioxidant activities as previously showed by our group. We have investigated the effect of EECp on the cyclophosphamide-induced HC. Cystitis was induced in male Wistar rats by the injection of cyclophosphamide. These animals were pretreated with EECp (100–400 mg/kg), vehicle, or mesna. Myeloperoxidase activity and malondialdehyde formation were measured in urinary bladder and other tissues. Bladder edema and histopathological alterations and serum nitric oxide metabolites concentration mathematical equation were also evaluated. Treatment with EECp (100–400 mg/kg) or mesna impaired the increase of myeloperoxidase activity in urinary bladder and the serum mathematical equation induced by cyclophosphamide but did not reduce edema in this tissue, as did mesna. Total histological score was reduced by EECp (100 mg/kg). Lung myeloperoxidase activity, which was increased by cyclophosphamide, was decreased significantly by EECp (400 mg/kg). EECp also diminished the malondialdehyde formation in bladder, lung, and spleen, although these parameters were not affected by cyclophosphamide. These results indicate that EECp reduced urinary bladder damage during cyclophosphamide-induced HC in rats.reponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/23841/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALEthanolExtractInnerBarkCaesalpiniaPyramidalis.pdfEthanolExtractInnerBarkCaesalpiniaPyramidalis.pdfapplication/pdf1495572https://ri.ufs.br/jspui/bitstream/riufs/23841/2/EthanolExtractInnerBarkCaesalpiniaPyramidalis.pdf2f2984b19cc79479b38af8c2cd8e3e57MD52riufs/238412025-11-12 16:02:54.545oai:oai:ri.ufs.br:repo_01:riufs/23841TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkNvbSBhIGFwcmVzZW50YcOnw6NvIGRlc3RhIGxpY2Vuw6dhLCB2b2PDqiAobyBhdXRvcihlcykgb3UgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBkZSBhdXRvcikgY29uY2VkZSDDoCBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkZSBTZXJnaXBlIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSByZXByb2R1emlyIHNldSB0cmFiYWxobyBubyBmb3JtYXRvIGVsZXRyw7RuaWNvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mgw6F1ZGlvIG91IHbDrWRlby4KClZvY8OqIGNvbmNvcmRhIHF1ZSBhIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRlIFNlcmdpcGUgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250ZcO6ZG8sIHRyYW5zcG9yIHNldSB0cmFiYWxobyBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIHRhbWLDqW0gY29uY29yZGEgcXVlIGEgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgU2VyZ2lwZSBwb2RlIG1hbnRlciBtYWlzIGRlIHVtYSBjw7NwaWEgZGUgc2V1IHRyYWJhbGhvIHBhcmEgZmlucyBkZSBzZWd1cmFuw6dhLCBiYWNrLXVwIGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIGRlY2xhcmEgcXVlIHNldSB0cmFiYWxobyDDqSBvcmlnaW5hbCBlIHF1ZSB2b2PDqiB0ZW0gbyBwb2RlciBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gVm9jw6ogdGFtYsOpbSBkZWNsYXJhIHF1ZSBvIGRlcMOzc2l0bywgcXVlIHNlamEgZGUgc2V1IGNvbmhlY2ltZW50bywgbsOjbyBpbmZyaW5nZSBkaXJlaXRvcyBhdXRvcmFpcyBkZSBuaW5ndcOpbS4KCkNhc28gbyB0cmFiYWxobyBjb250ZW5oYSBtYXRlcmlhbCBxdWUgdm9jw6ogbsOjbyBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2PDqiBkZWNsYXJhIHF1ZSBvYnRldmUgYSBwZXJtaXNzw6NvIGlycmVzdHJpdGEgZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIHBhcmEgY29uY2VkZXIgw6AgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgU2VyZ2lwZSBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7Dp2EsIGUgcXVlIGVzc2UgbWF0ZXJpYWwgZGUgcHJvcHJpZWRhZGUgZGUgdGVyY2Vpcm9zIGVzdMOhIGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3Ugbm8gY29udGXDumRvLgoKQSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkZSBTZXJnaXBlIHNlIGNvbXByb21ldGUgYSBpZGVudGlmaWNhciBjbGFyYW1lbnRlIG8gc2V1IG5vbWUocykgb3UgbyhzKSBub21lKHMpIGRvKHMpIApkZXRlbnRvcihlcykgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIGRvIHRyYWJhbGhvLCBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIGFsw6ltIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7Dp2EuIAo=Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2025-11-12T19:02:54Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
title The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
spellingShingle The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
Morais, Janaína Pereira
Hemorrhagic cystitis
Cyclophosphamide therapy
Ethanol extract
Caesalpinia pyramidalis
title_short The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
title_full The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
title_fullStr The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
title_full_unstemmed The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
title_sort The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
author Morais, Janaína Pereira
author_facet Morais, Janaína Pereira
Pereira, Denyson Santana
Matos, Alexandre Santos
Santana, Danielle Gomes
Santos, Cliomar Alves dos
Estevam, Charles dos Santos
Fakhouri, Ricardo
De Lucca Junior, Waldecy
Camargo, Enilton Aparecido
author_role author
author2 Pereira, Denyson Santana
Matos, Alexandre Santos
Santana, Danielle Gomes
Santos, Cliomar Alves dos
Estevam, Charles dos Santos
Fakhouri, Ricardo
De Lucca Junior, Waldecy
Camargo, Enilton Aparecido
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Morais, Janaína Pereira
Pereira, Denyson Santana
Matos, Alexandre Santos
Santana, Danielle Gomes
Santos, Cliomar Alves dos
Estevam, Charles dos Santos
Fakhouri, Ricardo
De Lucca Junior, Waldecy
Camargo, Enilton Aparecido
dc.subject.eng.fl_str_mv Hemorrhagic cystitis
Cyclophosphamide therapy
Ethanol extract
Caesalpinia pyramidalis
topic Hemorrhagic cystitis
Cyclophosphamide therapy
Ethanol extract
Caesalpinia pyramidalis
description New York
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2025-11-12T19:02:49Z
dc.date.available.fl_str_mv 2025-11-12T19:02:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORAIS, J. P. et al. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats. The Scientific World Journal, New York, n. 1, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2013/694010. Acesso em: 12 nov. 2025.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/jspui/handle/riufs/23841
dc.identifier.issn.none.fl_str_mv 1537-744X
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
identifier_str_mv MORAIS, J. P. et al. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats. The Scientific World Journal, New York, n. 1, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2013/694010. Acesso em: 12 nov. 2025.
1537-744X
Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
url https://ri.ufs.br/jspui/handle/riufs/23841
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv The Scientific World Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
instname:Universidade Federal de Sergipe (UFS)
instacron:UFS
instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
institution UFS
reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
bitstream.url.fl_str_mv https://ri.ufs.br/jspui/bitstream/riufs/23841/1/license.txt
https://ri.ufs.br/jspui/bitstream/riufs/23841/2/EthanolExtractInnerBarkCaesalpiniaPyramidalis.pdf
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