Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium

Bibliographic Details
Main Author: Conde Garcia, Eduardo Antonio
Publication Date: 2003
Other Authors: Nascimento, Vanessa Tavares do, Santos, Angela Barreto Santiago
Format: Article
Language: eng
Source: Repositório Institucional da UFS
Download full: https://ri.ufs.br/jspui/handle/riufs/20328
Summary: Ribeirão Preto
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spelling Conde Garcia, Eduardo AntonioNascimento, Vanessa Tavares doSantos, Angela Barreto Santiago2024-10-24T23:58:13Z2024-10-24T23:58:13Z2003CONDE GARCIA, E. A.; NASCIMENTO, V. T.; SANTOS, A. B. S. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 36, n. 5, p. 661-668, maio 2003. Disponível em: https://www.scielo.br/j/bjmbr/a/zZWPRh3QRtRWGhy7Nr3TTbH/?format=pdf&lang=en. Acesso em: 24 out. 2024.0100-879X1414-431Xhttps://ri.ufs.br/jspui/handle/riufs/20328Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchHeart contractilityGuinea pigMyocardial inotropismPsidium guajava L.Folk medicineContratilidade miocárdicaInotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atriuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRibeirão PretoMany pharmacological effects have been ascribed to extracts of Psidium guajava L. (guava) leaves. However, in spite of its widespread use in Brazilian folk medicine and a reasonable number of scientific reports about it, we could not find any study dealing with its action on the mammalian myocardium. In the present study, by measuring isometric force, we observed that the crude extract of P. guajava (water-alcohol extract obtained by macerating dry leaves) depresses the guinea pig atrial contractility in a concentration-dependent fashion (N = 8 hearts, 15 trials). The compound with cardiac activity was concentrated by extraction in a Soxhlet apparatus using 17 M glacial acetic acid after removing the less polar fractions (hexane, chloroform, acetone, ethanol and methanol), suggesting that this compound is a highly polar substance. In the isolated guinea pig left atrium the acetic acid fraction (10-800 mg/l) of P. guajava 1) reversibly decreased myocardial force in a concentration-dependent fashion (EC50 = 0.07g/l, N = 5 hearts, 9 trials, P<0.05), 2) increased the atrial relaxation time measured at 20% of the force amplitude up to 35% (91 ± 15 to 123 ± 30 ms, N = 3 hearts, 6 trials, P<0.05), 3) abolished the positive staircase effect (Bowditch phenomenon) in a concentration-dependent fashion suggesting a decrease of the cellular inward calcium current (N = 4 hearts, 8 trials, P<0.05), and 4) its inotropic effect was abolished by cholinergic receptor blockade with 1.5 mM atropine sulfate, indicating a cholinergic involvement in the mechanism of action of the extract (N = 7 hearts, 15 trials, P<0.05). The acetic acid extract was 20 times more potent than crude extract (EC50 = 1.4 g/l). The results showed that extracts from P. guajava leaves depress myocardial inotropism.reponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/20328/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALInotropicEffectsPsidiumGuajava.pdfInotropicEffectsPsidiumGuajava.pdfapplication/pdf871650https://ri.ufs.br/jspui/bitstream/riufs/20328/2/InotropicEffectsPsidiumGuajava.pdf8a7b7778d5f9e3cbd11b10b4e7866ad9MD52riufs/203282024-10-24 20:58:18.231oai:oai:ri.ufs.br:repo_01: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2024-10-24T23:58:18Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
title Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
spellingShingle Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
Conde Garcia, Eduardo Antonio
Heart contractility
Guinea pig
Myocardial inotropism
Psidium guajava L.
Folk medicine
Contratilidade miocárdica
title_short Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
title_full Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
title_fullStr Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
title_full_unstemmed Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
title_sort Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
author Conde Garcia, Eduardo Antonio
author_facet Conde Garcia, Eduardo Antonio
Nascimento, Vanessa Tavares do
Santos, Angela Barreto Santiago
author_role author
author2 Nascimento, Vanessa Tavares do
Santos, Angela Barreto Santiago
author2_role author
author
dc.contributor.author.fl_str_mv Conde Garcia, Eduardo Antonio
Nascimento, Vanessa Tavares do
Santos, Angela Barreto Santiago
dc.subject.eng.fl_str_mv Heart contractility
Guinea pig
Myocardial inotropism
Psidium guajava L.
Folk medicine
topic Heart contractility
Guinea pig
Myocardial inotropism
Psidium guajava L.
Folk medicine
Contratilidade miocárdica
dc.subject.por.fl_str_mv Contratilidade miocárdica
description Ribeirão Preto
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2024-10-24T23:58:13Z
dc.date.available.fl_str_mv 2024-10-24T23:58:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CONDE GARCIA, E. A.; NASCIMENTO, V. T.; SANTOS, A. B. S. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 36, n. 5, p. 661-668, maio 2003. Disponível em: https://www.scielo.br/j/bjmbr/a/zZWPRh3QRtRWGhy7Nr3TTbH/?format=pdf&lang=en. Acesso em: 24 out. 2024.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/jspui/handle/riufs/20328
dc.identifier.issn.none.fl_str_mv 0100-879X
1414-431X
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
identifier_str_mv CONDE GARCIA, E. A.; NASCIMENTO, V. T.; SANTOS, A. B. S. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 36, n. 5, p. 661-668, maio 2003. Disponível em: https://www.scielo.br/j/bjmbr/a/zZWPRh3QRtRWGhy7Nr3TTbH/?format=pdf&lang=en. Acesso em: 24 out. 2024.
0100-879X
1414-431X
Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
url https://ri.ufs.br/jspui/handle/riufs/20328
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
instname:Universidade Federal de Sergipe (UFS)
instacron:UFS
instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
institution UFS
reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
bitstream.url.fl_str_mv https://ri.ufs.br/jspui/bitstream/riufs/20328/1/license.txt
https://ri.ufs.br/jspui/bitstream/riufs/20328/2/InotropicEffectsPsidiumGuajava.pdf
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repository.name.fl_str_mv Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)
repository.mail.fl_str_mv repositorio@academico.ufs.br
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