Multisite non-invasive brain stimulation in Parkinson’s disease: a scoping review

• Main Author: Godeiro Junior, Clécio de Oliveira
• Publication Date: 2021
• Other Authors: Machado, Camila Beatriz da Silva, Silva, Letícia Maria da, Gonçalves, Alessandra Feitosa, Andrade, Palloma Rodrigues de, Mendes, Cristina Katya Torres Teixeira, Assis, Thais Josy Castro Freire de, Andrade, Suellen Marinho
• Format: Article
• Language: eng
• Source: Repositório Institucional da UFRN
• Download full: https://repositorio.ufrn.br/handle/123456789/52861
• topic: Parkinson’s disease; non-invasive brain stimulation; transcranial magnetic stimulation; transcranial direct current stimulation

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by cardinal motor symptoms in addition to cognitive impairment. New insights concerning multisite non-invasive brain stimulation effects have been gained, which can now be used to develop innovative treatment approaches. Objective: Map the researchs involving multisite non-invasive brain stimulation in PD, synthesize the available evidence and discuss future directions. Methods: The databases PubMed, PsycINFO, CINAHL, LILACS and The Cochrane Library were searched from inception until April 2020, without restrictions on the date of publication or the language in which it was published. The reviewers worked in pairs and sequentially evaluated the titles, abstracts and then the full text of all publications identified as potentially relevant. Results: Twelve articles met the inclusion criteria. The target brain regions included mainly the combination of a motor and a frontal area, such as stimulation of the primary motor córtex associated with the dorsolateral prefrontal cortex. Most of the trials showed that this modality was only more effective for the motor component, or for the cognitive and/or non-motor, separately. Conclusions: Despite the results being encouraging for the use of the multisite aproach, the indication for PD management should be carried out with caution and deserves scientific deepening.