The Treatment of Brain Arteriovenous Malformation Study (TOBAS): a preliminary inter-and intra-rater agreement study on patient management

• Main Author: Fahed, Robert
• Publication Date: 2017
• Other Authors: Batista, André Lima, Darsaut, Tim E., Gentric, Jean-Christophe, Ducroux, Célina, Chaalala, Chiraz, Roberge, David, Bojanowski, Michel W., Weill, Alain, Roy, Daniel, Magro, Elsa, Raymond, Jean
• Format: Article
• Language: eng
• Source: Repositório Institucional da UFRN
• dARK ID: ark:/41046/001300000w9z4
• Download full: https://repositorio.ufrn.br/handle/123456789/52414
• topic: AVM; Agreement; Kappa; Arteriovenous malformation

Object. – The best management of brain arteriovenous malformation (bAVM) patients remains unknown. Randomized allocation may be more readily accepted when there is uncertainty and disagreement regarding the management of potential participants. In planning for a trial, we aimed to assess variability and agreement among physicians managing bAVM patients. Methods. – A portfolio composed of 35 patients was sent to 47 clinicians of various specialties managing bAVM patients. For each patient, physicians were asked their best management deci sion (surgery/embolization/radiosurgery/conservative), their confidence level, and whether they would include the patientin a randomized trial comparing conservative and curative management. Seven physi cians, who had access to all images of each patient, independently responded twice, to assess inter and intra-rater agreement using kappa statistics. Results. – The inter-rater agreement (30 raters, including 16 neuroradiologists) for best management decision was only “fair” ( [95%CI] = 0.210[0.157; 0.295]). Agreement remained below ‘substantial’( < .6) between physicians of the same specialty, and when no distinctions were made between various treat ments (when responses were dichotomized as conservative versus curative). With access to all images the inter-rater agreement remained fair. The intra-rater agreement reached “substantial” only for the dichotomized decisions. Responding clinicians were willing to include 54.4% of patients (mainly unrup tured bAVMs) in a randomized trial. Conclusion. – There is a lack of agreement among clinicians involved in the management of bAVM patients. In this study a substantial proportion of clinicians were willing to offer randomized allocation of man agement options to a substantial number of patients.