Concomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritis

• Main Author: Keiserman, Briele
• Publication Date: 2013
• Other Authors: Ronchetti, Maria Rita, Monticielo, Odirlei André, Keiserman, Mauro Waldemar, Staub, Henrique Luiz
• Format: Article
• Language: eng
• Source: Repositório Institucional da UFRGS
• Download full: http://hdl.handle.net/10183/96787
• topic: Lupus eritematoso sistêmico; Nefrite lúpica; Systemic lupus erythematosus; Lupus nephritis; IgG and IgM anti-dsDNA antibodies

Previous reports proposed that the IgM anti-dsDNA antibody is protective for lupus nephritis. In this crosssectional study, we aimed to compare clinical features of systemic lupus erythematosus (SLE) patients positive for IgG anti-dsDNA alone with those presenting both IgG and IgM anti-dsDNA. Anti-dsDNA antibodies, urinary examination and complement levels were assessed in the day of appointment. IgG and IgM anti-dsDNA antibodies were detected by indirect immunofluorescence. Fifty-eight SLE patients (93.1% female, 81% European-derived, mean age 42.8±14.7 years, mean duration of disease 10.9±8 years) positive for IgG anti-dsDNA entered the study. Of those, 15 were also positive for the IgM anti-dsDNA isotype. The group with both isotypes showed significant less frequency of active nephritis (sediment changes and proteinuria) when compared to patients with IgG anti-dsDNA alone (6.7% versus 34.9%, p=0.046). These data suggest a nephroprotective role for IgM anti-dsDNA and a distinct biologic behavior for this isotype in SLE.