Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil

Detalhes bibliográficos
Autor(a) principal: Bajerski, Lisiane
Data de Publicação: 2013
Outros Autores: Paim, Clésio Soldateli, Pereira, Andréa Garcia, Dias, Carolina Lupi, Rossi, Rochele Cassanta, Todeschini, Vítor, Steppe, Martin, Bergold, Ana Maria, Froehlich, Pedro Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/73025
Resumo: A stability-indicating method using MEKC was validated for the analysis of olmesartan medoxomil in tablets. Successful separation was achieved using a fused silica capillary (40 cm x 50 μm i.d.); background electrolyte consisted of a combination of 10 mmol L-1 borate buffer and 5 mmol L-1 anionic detergent sodium dodecyl sulfate (95:5; v/v) pH 6.5; hydrodynamic mode at 50 mBar for 5 s; 25 kV separation voltage at 25 ºC; and column temperature 25 ºC with detection at 257 nm. The proposed method, validated following ICH guidelines, was applied to the determination of this antihypertensive with good results compared with an LC method.
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spelling Bajerski, LisianePaim, Clésio SoldateliPereira, Andréa GarciaDias, Carolina LupiRossi, Rochele CassantaTodeschini, VítorSteppe, MartinBergold, Ana MariaFroehlich, Pedro Eduardo2013-07-03T01:43:53Z20130100-4042http://hdl.handle.net/10183/73025000881771A stability-indicating method using MEKC was validated for the analysis of olmesartan medoxomil in tablets. Successful separation was achieved using a fused silica capillary (40 cm x 50 μm i.d.); background electrolyte consisted of a combination of 10 mmol L-1 borate buffer and 5 mmol L-1 anionic detergent sodium dodecyl sulfate (95:5; v/v) pH 6.5; hydrodynamic mode at 50 mBar for 5 s; 25 kV separation voltage at 25 ºC; and column temperature 25 ºC with detection at 257 nm. The proposed method, validated following ICH guidelines, was applied to the determination of this antihypertensive with good results compared with an LC method.application/pdfengQuímica nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 36, n. 1, (2013), p. 34-39Cromatografia capilar eletrocinética micelarCromatografia liquidaOlmesartana medoxomilaOlmesartan medoxomilMEKCLCStability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomilinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000881771.pdf000881771.pdfTexto completo (inglês)application/pdf356870http://www.lume.ufrgs.br/bitstream/10183/73025/1/000881771.pdf3f5be01105979b34e1b8bf6b3a683c0dMD51TEXT000881771.pdf.txt000881771.pdf.txtExtracted Texttext/plain30360http://www.lume.ufrgs.br/bitstream/10183/73025/2/000881771.pdf.txt72b23a7173b55a4d78b38bbf03a97286MD52THUMBNAIL000881771.pdf.jpg000881771.pdf.jpgGenerated Thumbnailimage/jpeg1867http://www.lume.ufrgs.br/bitstream/10183/73025/3/000881771.pdf.jpg49bb5cb02e553cec2d717e46ff6b2befMD5310183/730252018-10-15 07:43:54.235oai:www.lume.ufrgs.br:10183/73025Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2018-10-15T10:43:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
title Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
spellingShingle Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
Bajerski, Lisiane
Cromatografia capilar eletrocinética micelar
Cromatografia liquida
Olmesartana medoxomila
Olmesartan medoxomil
MEKC
LC
title_short Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
title_full Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
title_fullStr Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
title_full_unstemmed Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
title_sort Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil
author Bajerski, Lisiane
author_facet Bajerski, Lisiane
Paim, Clésio Soldateli
Pereira, Andréa Garcia
Dias, Carolina Lupi
Rossi, Rochele Cassanta
Todeschini, Vítor
Steppe, Martin
Bergold, Ana Maria
Froehlich, Pedro Eduardo
author_role author
author2 Paim, Clésio Soldateli
Pereira, Andréa Garcia
Dias, Carolina Lupi
Rossi, Rochele Cassanta
Todeschini, Vítor
Steppe, Martin
Bergold, Ana Maria
Froehlich, Pedro Eduardo
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bajerski, Lisiane
Paim, Clésio Soldateli
Pereira, Andréa Garcia
Dias, Carolina Lupi
Rossi, Rochele Cassanta
Todeschini, Vítor
Steppe, Martin
Bergold, Ana Maria
Froehlich, Pedro Eduardo
dc.subject.por.fl_str_mv Cromatografia capilar eletrocinética micelar
Cromatografia liquida
Olmesartana medoxomila
topic Cromatografia capilar eletrocinética micelar
Cromatografia liquida
Olmesartana medoxomila
Olmesartan medoxomil
MEKC
LC
dc.subject.eng.fl_str_mv Olmesartan medoxomil
MEKC
LC
description A stability-indicating method using MEKC was validated for the analysis of olmesartan medoxomil in tablets. Successful separation was achieved using a fused silica capillary (40 cm x 50 μm i.d.); background electrolyte consisted of a combination of 10 mmol L-1 borate buffer and 5 mmol L-1 anionic detergent sodium dodecyl sulfate (95:5; v/v) pH 6.5; hydrodynamic mode at 50 mBar for 5 s; 25 kV separation voltage at 25 ºC; and column temperature 25 ºC with detection at 257 nm. The proposed method, validated following ICH guidelines, was applied to the determination of this antihypertensive with good results compared with an LC method.
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-07-03T01:43:53Z
dc.date.issued.fl_str_mv 2013
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/73025
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000881771
identifier_str_mv 0100-4042
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url http://hdl.handle.net/10183/73025
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 36, n. 1, (2013), p. 34-39
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instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
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