Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat

Bibliographic Details
Main Author: Haanwinckel, M. A.
Publication Date: 1995
Other Authors: Elias, L. K., Favaretto, A. L. V., Gutkowska, J., Mccann, S. M.
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/12934
Summary: p. 7902-7906
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spelling Haanwinckel, M. A.Elias, L. K.Favaretto, A. L. V.Gutkowska, J.Mccann, S. M.Haanwinckel, M. A.Elias, L. K.Favaretto, A. L. V.Gutkowska, J.Mccann, S. M.2013-09-12T20:18:22Z2013-09-12T20:18:22Z1995http://www.repositorio.ufba.br/ri/handle/ri/12934v. 92p. 7902-7906Our previous studies have shown that stimulation of the anterior ventral third ventricular region increases atrial natriuretic peptide (ANP) release, whereas lesions of this structure, the median eminence, or removal of the neural lobe of the pituitary block ANP release induced by blood volume expansion (BVE). These results indicate that participation of the central nervous system is crucial in these responses, possibly through mediation by neurohypophysial hormones. In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release. Oxytocin (1-10 nmol) injected i.p. caused significant, dose-dependent increases in urinary osmolality, natriuresis, and kaliuresis. A delayed antidiuretic effect was also observed. Plasma ANP concentrations increased nearly 4-fold (P < 0.01) 20 min after i.p. oxytocin (10 nmol), but there was no change in plasma ANP values in control rats. When oxytocin (1 or 10 nmol) was injected i.v., it also induced a dose-related increase in plasma ANP at 5 min (P < 0.001). BVE by intra-atrial injection of isotonic saline induced a rapid (5 min postinjection) increase in plasma oxytocin and ANP concentrations and a concomitant decrease in plasma arginine vasopressin concentration. Results were similar with hypertonic volume expansion, except that this induced a transient (5 min) increase in plasma arginine vasopressin. The findings are consistent with the hypothesis that baroreceptor activation of the central nervous system by BVE stimulates the release of oxytocin from the neurohypophysis. This oxytocin then circulates to the right atrium to induce release ofANP, which circulates to the kidney and induces natriuresis and diuresis, which restore body fluid volume to normal levels.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-12T19:02:23Z No. of bitstreams: 1 1111111111111s.pdf: 1114424 bytes, checksum: 9c3d34015dad3fcc97a3e0486ee3248a (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-09-12T20:18:22Z (GMT) No. of bitstreams: 1 1111111111111s.pdf: 1114424 bytes, checksum: 9c3d34015dad3fcc97a3e0486ee3248a (MD5)Made available in DSpace on 2013-09-12T20:18:22Z (GMT). No. of bitstreams: 1 1111111111111s.pdf: 1114424 bytes, checksum: 9c3d34015dad3fcc97a3e0486ee3248a (MD5) Previous issue date: 1995SalvadorProc. Natl. Acad. Sci. USAhttp://www.pnas.org/content/92/17/7902reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAVasopressinKaliuresisDiuresisUrine osmolalityOxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the ratProc. Natl. Acad. Sci. 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dc.title.pt_BR.fl_str_mv Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
dc.title.alternative.pt_BR.fl_str_mv Proc. Natl. Acad. Sci. USA
title Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
spellingShingle Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
Haanwinckel, M. A.
Vasopressin
Kaliuresis
Diuresis
Urine osmolality
title_short Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
title_full Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
title_fullStr Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
title_full_unstemmed Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
title_sort Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat
author Haanwinckel, M. A.
author_facet Haanwinckel, M. A.
Elias, L. K.
Favaretto, A. L. V.
Gutkowska, J.
Mccann, S. M.
author_role author
author2 Elias, L. K.
Favaretto, A. L. V.
Gutkowska, J.
Mccann, S. M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Haanwinckel, M. A.
Elias, L. K.
Favaretto, A. L. V.
Gutkowska, J.
Mccann, S. M.
Haanwinckel, M. A.
Elias, L. K.
Favaretto, A. L. V.
Gutkowska, J.
Mccann, S. M.
dc.subject.por.fl_str_mv Vasopressin
Kaliuresis
Diuresis
Urine osmolality
topic Vasopressin
Kaliuresis
Diuresis
Urine osmolality
description p. 7902-7906
publishDate 1995
dc.date.issued.fl_str_mv 1995
dc.date.accessioned.fl_str_mv 2013-09-12T20:18:22Z
dc.date.available.fl_str_mv 2013-09-12T20:18:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12934
dc.identifier.number.pt_BR.fl_str_mv v. 92
url http://www.repositorio.ufba.br/ri/handle/ri/12934
identifier_str_mv v. 92
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Proc. Natl. Acad. Sci. USA
publisher.none.fl_str_mv Proc. Natl. Acad. Sci. USA
dc.source.pt_BR.fl_str_mv http://www.pnas.org/content/92/17/7902
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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