Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities

Detalhes bibliográficos
Autor(a) principal: Cunha, Silvio do Desterro
Data de Publicação: 2007
Outros Autores: Bastos, Rodrigo M., Silva, Priscila de O., Costa, Giselle A. Nobre, Vencato, Ivo, Lariucci, Carlito, Napolitano, Hamilton B., Oliveira, Cecília M. A. de, Kato, Lucília, Silva, Cleuza C. da, Menezes, Diego, Santos, Marcos André Vannier dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14723
Resumo: Texto completo: acesso restrito. p.111-119
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spelling Cunha, Silvio do DesterroBastos, Rodrigo M.Silva, Priscila de O.Costa, Giselle A. NobreVencato, IvoLariucci, CarlitoNapolitano, Hamilton B.Oliveira, Cecília M. A. deKato, LucíliaSilva, Cleuza C. daMenezes, DiegoSantos, Marcos André Vannier dosCunha, Silvio do DesterroBastos, Rodrigo M.Silva, Priscila de O.Costa, Giselle A. NobreVencato, IvoLariucci, CarlitoNapolitano, Hamilton B.Oliveira, Cecília M. A. deKato, LucíliaSilva, Cleuza C. daMenezes, DiegoSantos, Marcos André Vannier dos2014-03-12T12:00:37Z20070026-9247http://repositorio.ufba.br/ri/handle/ri/14723v. 138, n. 2Texto completo: acesso restrito. p.111-119This work describes a two-step, one-pot synthetic method for the formal aza-[3 + 3] cycloaddition between N-alkyl substituted enaminones and benzoyl isothiocyanate, which afforded 4-thioxopyrimidines in reasonable yields. Reaction of acyclic enaminone with a sterically hindered group attached to the nitrogen atom afforded pyridine-2-thione, yet in low yield. The antibacterial, antifungal, and trypanocidal activities of the thioxopyrimidines were evaluated and five compounds exhibited moderate activity against Candida albicans, Micrococcus luteus, and Trypanosoma cruzi. The solid state structures of a thioxopyrimidine, an organic disulfide, and a 1,2,4-triazole were determined by X-ray diffraction analysis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-12T12:00:37Z No. of bitstreams: 1 art%3A10.1007%2Fs00706-006-0577-y.pdf: 336694 bytes, checksum: 95e7287cb3a43f33fd40c9fbef11ab45 (MD5)Made available in DSpace on 2014-03-12T12:00:37Z (GMT). No. of bitstreams: 1 art%3A10.1007%2Fs00706-006-0577-y.pdf: 336694 bytes, checksum: 95e7287cb3a43f33fd40c9fbef11ab45 (MD5) Previous issue date: 2007http://dx.doi.org/10.1007/s00706-006-0577-yreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACyclizationsEnaminonesHeterocyclesPyrimidine-4-thionesX-ray structure determinationSynthesis and structural studies of 4-thioxopyrimidines with antimicrobial activitiesChemical Monthly / Monatshefte für Chemieinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALart%3A10.1007%2Fs00706-006-0577-y.pdfart%3A10.1007%2Fs00706-006-0577-y.pdfapplication/pdf336694https://repositorio.ufba.br/bitstream/ri/14723/1/art%253A10.1007%252Fs00706-006-0577-y.pdf95e7287cb3a43f33fd40c9fbef11ab45MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14723/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTart%3A10.1007%2Fs00706-006-0577-y.pdf.txtart%3A10.1007%2Fs00706-006-0577-y.pdf.txtExtracted texttext/plain32288https://repositorio.ufba.br/bitstream/ri/14723/3/art%253A10.1007%252Fs00706-006-0577-y.pdf.txt4496e5e776484f957fe4b4c555f8affcMD53ri/147232022-08-08 13:17:50.06oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestrepositorio@ufba.bropendoar:19322022-08-08T16:17:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
dc.title.alternative.pt_BR.fl_str_mv Chemical Monthly / Monatshefte für Chemie
title Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
spellingShingle Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
Cunha, Silvio do Desterro
Cyclizations
Enaminones
Heterocycles
Pyrimidine-4-thiones
X-ray structure determination
title_short Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
title_full Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
title_fullStr Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
title_full_unstemmed Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
title_sort Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
author Cunha, Silvio do Desterro
author_facet Cunha, Silvio do Desterro
Bastos, Rodrigo M.
Silva, Priscila de O.
Costa, Giselle A. Nobre
Vencato, Ivo
Lariucci, Carlito
Napolitano, Hamilton B.
Oliveira, Cecília M. A. de
Kato, Lucília
Silva, Cleuza C. da
Menezes, Diego
Santos, Marcos André Vannier dos
author_role author
author2 Bastos, Rodrigo M.
Silva, Priscila de O.
Costa, Giselle A. Nobre
Vencato, Ivo
Lariucci, Carlito
Napolitano, Hamilton B.
Oliveira, Cecília M. A. de
Kato, Lucília
Silva, Cleuza C. da
Menezes, Diego
Santos, Marcos André Vannier dos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Silvio do Desterro
Bastos, Rodrigo M.
Silva, Priscila de O.
Costa, Giselle A. Nobre
Vencato, Ivo
Lariucci, Carlito
Napolitano, Hamilton B.
Oliveira, Cecília M. A. de
Kato, Lucília
Silva, Cleuza C. da
Menezes, Diego
Santos, Marcos André Vannier dos
Cunha, Silvio do Desterro
Bastos, Rodrigo M.
Silva, Priscila de O.
Costa, Giselle A. Nobre
Vencato, Ivo
Lariucci, Carlito
Napolitano, Hamilton B.
Oliveira, Cecília M. A. de
Kato, Lucília
Silva, Cleuza C. da
Menezes, Diego
Santos, Marcos André Vannier dos
dc.subject.por.fl_str_mv Cyclizations
Enaminones
Heterocycles
Pyrimidine-4-thiones
X-ray structure determination
topic Cyclizations
Enaminones
Heterocycles
Pyrimidine-4-thiones
X-ray structure determination
description Texto completo: acesso restrito. p.111-119
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-03-12T12:00:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14723
dc.identifier.issn.none.fl_str_mv 0026-9247
dc.identifier.number.pt_BR.fl_str_mv v. 138, n. 2
identifier_str_mv 0026-9247
v. 138, n. 2
url http://repositorio.ufba.br/ri/handle/ri/14723
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1007/s00706-006-0577-y
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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