C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis

Bibliographic Details
Main Author: Correia, Luis Cláudio Lemos
Publication Date: 2010
Other Authors: Esteves, José Péricles
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/6190
Summary: p.76-85
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spelling Correia, Luis Cláudio LemosEsteves, José PériclesCorreia, Luis Cláudio LemosEsteves, José Péricles2012-06-20T14:11:36Z2012-06-20T14:11:36Z20100066-782Xhttp://www.repositorio.ufba.br/ri/handle/ri/6190v. 97, n. 1p.76-85Despite the association between high-sensitivity C-reactive protein (CRP) and recurrent events in non-ST elevation acute coronary syndromes (ACS), routine determination of this marker has not been recommended. In order to verify whether the current scientific evidence justifies the inclusion of CRP for risk stratification at hospital admission of patients with ACS, we carried out a systematic review and meta-analysis of the studies indexed in MEDLINE, SciELO or LILACS, with the following inclusion criteria: prospective cohort design and assessment of the prognostic value of CPR, as measured using a high-sensitivity method at the moment of hospital admission of patients with ACS. Nineteen studies met the inclusion criteria. In relation to the long-term follow-up, there was a consistent association between CRP and cardiovascular events, with an overall odds ratio (OR) of 4.6 (95% CI = 2.3 – 7.6) and overall multivariate OR of 2.5 (95% CI = 1.8-3.4). As for the short-term, nine studies were positive and six were negative, with an overall OR of 1.65 (95% CI = 1.2-2.3). The overall multivariate OR was not obtained for the short-term follow-up, because this measurement was described only in three heterogeneous studies. Only two short-term studies analyzed the incremental predictive value of CRP in relation to multivariate models, with contradicting results. In conclusion, the small number of assessments of the incremental value of CRP, in conjunction with controversial results regarding the independent predictive value of CRP for short-term events does not support the recommendation of the routine use of CRP for risk stratification at admission of patients with ACS.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-06-20T14:11:36Z No. of bitstreams: 1 Correia, Luís C. L..pdf: 606306 bytes, checksum: 2f24dc2b275bd0878fb609d8367f1b45 (MD5)Made available in DSpace on 2012-06-20T14:11:36Z (GMT). No. of bitstreams: 1 Correia, Luís C. L..pdf: 606306 bytes, checksum: 2f24dc2b275bd0878fb609d8367f1b45 (MD5) Previous issue date: 2011-03Rio de JaneiroArquivos Brasileiros de Cardiologiahttp://dx.doi.org/10.1590/S0066-782X2011005000032.reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAC-Reactive proteinAcute coronary syndromePrognosisMeta-analysisC-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysisArq. Bras. Cardiol.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALCorreia, Luís C. L..pdfCorreia, Luís C. L..pdfapplication/pdf606306https://repositorio.ufba.br/bitstream/ri/6190/1/Correia%2c%20Lu%c3%ads%20C.%20L..pdf2f24dc2b275bd0878fb609d8367f1b45MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6190/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTCorreia, Luís C. L..pdf.txtCorreia, Luís C. 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dc.title.pt_BR.fl_str_mv C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
dc.title.alternative.pt_BR.fl_str_mv Arq. Bras. Cardiol.
title C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
spellingShingle C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
Correia, Luis Cláudio Lemos
C-Reactive protein
Acute coronary syndrome
Prognosis
Meta-analysis
title_short C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
title_full C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
title_fullStr C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
title_full_unstemmed C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
title_sort C-Reactive protein and outcomes in acute coronary syndromes: a systematic review and meta-analysis
author Correia, Luis Cláudio Lemos
author_facet Correia, Luis Cláudio Lemos
Esteves, José Péricles
author_role author
author2 Esteves, José Péricles
author2_role author
dc.contributor.author.fl_str_mv Correia, Luis Cláudio Lemos
Esteves, José Péricles
Correia, Luis Cláudio Lemos
Esteves, José Péricles
dc.subject.por.fl_str_mv C-Reactive protein
Acute coronary syndrome
Prognosis
Meta-analysis
topic C-Reactive protein
Acute coronary syndrome
Prognosis
Meta-analysis
description p.76-85
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-06-20T14:11:36Z
dc.date.available.fl_str_mv 2012-06-20T14:11:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6190
dc.identifier.issn.none.fl_str_mv 0066-782X
dc.identifier.number.pt_BR.fl_str_mv v. 97, n. 1
identifier_str_mv 0066-782X
v. 97, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6190
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Arquivos Brasileiros de Cardiologia
publisher.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2011005000032.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
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