Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?

Bibliographic Details
Main Author: Arruda, Valder Roberval
Publication Date: 1998
Other Authors: Grignolli, Carlos Roberto Escrivão, Gonçalves, Marilda de Souza, Soares, Manoel C. P., Menezes, Raimundo, Saad, Sara Teresinha Olalla, Costa, Fernando Ferreira
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/8235
Summary: Texto completo: acesso restrito. p.210–214
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spelling Arruda, Valder RobervalGrignolli, Carlos Roberto EscrivãoGonçalves, Marilda de SouzaSoares, Manoel C. P.Menezes, RaimundoSaad, Sara Teresinha OlallaCosta, Fernando FerreiraArruda, Valder RobervalGrignolli, Carlos Roberto EscrivãoGonçalves, Marilda de SouzaSoares, Manoel C. P.Menezes, RaimundoSaad, Sara Teresinha OlallaCosta, Fernando Ferreira2013-01-30T12:58:58Z19980009-9163http://www.repositorio.ufba.br/ri/handle/ri/8235v. 54, n. 3Texto completo: acesso restrito. p.210–214Environmental related diseases due to occupational carcinogens and toxic substances are a serious problem particularly in developing countries. The glutathione S-transferase system is fundamental for the detoxification of numerous carcinogens and mutagens. The individual inherited susceptibility to chemical carcinogenesis due to glutathione S-transferase mu (GSTMl) and theta (GSTTl) varies significantly among distinct ethnic groups. In this study we determined the prevalence of the null genotype of the GSTMl and GSTTl genes among individuals from three distinct Brazilian racial groups using a multi-plex-PCR methodology. The results showed that the highest prevalence of the null genotype for the GSTMl occurred among Caucasians (55%, allele frequency = 0.74), followed by 33% among Brazilian Black subjects (allele frequency = 0.57). and 20% among Amazonian Indians (allele frequency = 0.45). For GSTTl a homogenous distribution of the null genotype was found among Caucasian and African descendants (18.5 and 19% homozygotes, respectively, allele. frequency = 0.43). with a lower prevalence among Amazonian Indians (11% of homozygotes, a!lele frequency = 0.34). Whether the deficiency of the GST system contributes to a predisposition to environmental related carcinogenesis in specific popuiations in Brazil remains to be determined.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-28T15:49:41Z No. of bitstreams: 1 arruda.pdf: 1089919 bytes, checksum: c7244d91211a039bcbc37161018c2d63 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-01-30T12:58:58Z (GMT) No. of bitstreams: 1 arruda.pdf: 1089919 bytes, checksum: c7244d91211a039bcbc37161018c2d63 (MD5)Made available in DSpace on 2013-01-30T12:58:58Z (GMT). No. of bitstreams: 1 arruda.pdf: 1089919 bytes, checksum: c7244d91211a039bcbc37161018c2d63 (MD5) Previous issue date: 1998http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0004.1998.tb04286.x/pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADNA analyslsglutathone S-transferase mu geneglutathione S-transferase theta genemutations -PCRPrevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?Clinical Geneticsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALarruda.pdfarruda.pdfapplication/pdf1089919https://repositorio.ufba.br/bitstream/ri/8235/1/arruda.pdfc7244d91211a039bcbc37161018c2d63MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8235/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTarruda.pdf.txtarruda.pdf.txtExtracted texttext/plain0https://repositorio.ufba.br/bitstream/ri/8235/3/arruda.pdf.txtd41d8cd98f00b204e9800998ecf8427eMD53ri/82352022-07-05 14:03:15.81oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestrepositorio@ufba.bropendoar:19322022-07-05T17:03:15Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
dc.title.alternative.pt_BR.fl_str_mv Clinical Genetics
title Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
spellingShingle Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
Arruda, Valder Roberval
DNA analysls
glutathone S-transferase mu gene
glutathione S-transferase theta gene
mutations -PCR
title_short Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
title_full Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
title_fullStr Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
title_full_unstemmed Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
title_sort Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTMl) and theta (GSTTl) among distinct ethnic groutx from Brazil: relevance to enviromental carcinogenesis?
author Arruda, Valder Roberval
author_facet Arruda, Valder Roberval
Grignolli, Carlos Roberto Escrivão
Gonçalves, Marilda de Souza
Soares, Manoel C. P.
Menezes, Raimundo
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
author_role author
author2 Grignolli, Carlos Roberto Escrivão
Gonçalves, Marilda de Souza
Soares, Manoel C. P.
Menezes, Raimundo
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Arruda, Valder Roberval
Grignolli, Carlos Roberto Escrivão
Gonçalves, Marilda de Souza
Soares, Manoel C. P.
Menezes, Raimundo
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
Arruda, Valder Roberval
Grignolli, Carlos Roberto Escrivão
Gonçalves, Marilda de Souza
Soares, Manoel C. P.
Menezes, Raimundo
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
dc.subject.por.fl_str_mv DNA analysls
glutathone S-transferase mu gene
glutathione S-transferase theta gene
mutations -PCR
topic DNA analysls
glutathone S-transferase mu gene
glutathione S-transferase theta gene
mutations -PCR
description Texto completo: acesso restrito. p.210–214
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2013-01-30T12:58:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8235
dc.identifier.issn.none.fl_str_mv 0009-9163
dc.identifier.number.pt_BR.fl_str_mv v. 54, n. 3
identifier_str_mv 0009-9163
v. 54, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/8235
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0004.1998.tb04286.x/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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