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HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis

Bibliographic Details
Main Author: Porto, Maria Aurélia da Fonseca
Publication Date: 2001
Other Authors: Neva, Franklin A., Bittencourt, Helito, Lisboa, Waldir, Thompson, Robert, Alcântara, Luiz Carlos Júnior, Carvalho Filho, Edgar Marcelino de
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/7675
Summary: Texto completo: acesso restrito. p. 503–507
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spelling Porto, Maria Aurélia da FonsecaNeva, Franklin A.Bittencourt, HelitoLisboa, WaldirThompson, RobertAlcântara, Luiz Carlos JúniorCarvalho Filho, Edgar Marcelino dePorto, Maria Aurélia da FonsecaNeva, Franklin A.Bittencourt, HelitoLisboa, WaldirThompson, RobertAlcântara, Luiz Carlos JúniorCarvalho Filho, Edgar Marcelino de2012-12-19T17:29:27Z20010141-9838http://www.repositorio.ufba.br/ri/handle/ri/7675v. 23, n. 9Texto completo: acesso restrito. p. 503–507Eosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV-1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV-1 infection, strongyloidiasis with HTLV-1, HTLV-1 without strongyloidiasis and controls without either helminth infection or HTLV-1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV-1 had higher levels of interfron (IFN)-γ and interleukin (IL)-10 (P < 0·05) and lower levels of IL-5 and IgE (P < 0·05) than patients with strongyloidiasis without HTLV-1. There was an inverse relationship between IFN-γ and IL-5 (P = 0·01; rs = − 0·37) and between IFN-γ and parasite specific IgE (P = 0·01; rs = − 0·39), and a direct relationship between IFN-γ and IL-10 (P = 0·04; rs = 0·35). These data show that coinfection with HTLV-1 decreases IL-5 and IgE responses in patients with strongyloidiasis consistent with a relative switch from Th2 to Th1 response. Immunological responses such as these are important in the control of this helminthic infection.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-19T17:29:27Z No. of bitstreams: 1 j.1365-3024.2001.00407.pdf: 95167 bytes, checksum: 5466c786d6eeb307e0761d660b77ce00 (MD5)Made available in DSpace on 2012-12-19T17:29:27Z (GMT). No. of bitstreams: 1 j.1365-3024.2001.00407.pdf: 95167 bytes, checksum: 5466c786d6eeb307e0761d660b77ce00 (MD5) Previous issue date: 2001http://dx.doi.org/10.1046/j.1365-3024.2001.00407.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHTLV-1strongyloidiasisIgES. stercoralisHTLV-1 decreases Th2 type of immune response in patients with strongyloidiasisParasite Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALj.1365-3024.2001.00407.pdfj.1365-3024.2001.00407.pdfapplication/pdf95167https://repositorio.ufba.br/bitstream/ri/7675/1/j.1365-3024.2001.00407.pdf5466c786d6eeb307e0761d660b77ce00MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7675/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTj.1365-3024.2001.00407.pdf.txtj.1365-3024.2001.00407.pdf.txtExtracted texttext/plain25461https://repositorio.ufba.br/bitstream/ri/7675/3/j.1365-3024.2001.00407.pdf.txtae17e0344d22550c44b9ad9ee6c46b6aMD53ri/76752022-07-05 14:03:28.583oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestrepositorio@ufba.bropendoar:19322022-07-05T17:03:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
spellingShingle HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
Porto, Maria Aurélia da Fonseca
HTLV-1
strongyloidiasis
IgE
S. stercoralis
title_short HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
title_full HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
title_fullStr HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
title_full_unstemmed HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
title_sort HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
author Porto, Maria Aurélia da Fonseca
author_facet Porto, Maria Aurélia da Fonseca
Neva, Franklin A.
Bittencourt, Helito
Lisboa, Waldir
Thompson, Robert
Alcântara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Neva, Franklin A.
Bittencourt, Helito
Lisboa, Waldir
Thompson, Robert
Alcântara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Porto, Maria Aurélia da Fonseca
Neva, Franklin A.
Bittencourt, Helito
Lisboa, Waldir
Thompson, Robert
Alcântara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino de
Porto, Maria Aurélia da Fonseca
Neva, Franklin A.
Bittencourt, Helito
Lisboa, Waldir
Thompson, Robert
Alcântara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv HTLV-1
strongyloidiasis
IgE
S. stercoralis
topic HTLV-1
strongyloidiasis
IgE
S. stercoralis
description Texto completo: acesso restrito. p. 503–507
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-12-19T17:29:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7675
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 23, n. 9
identifier_str_mv 0141-9838
v. 23, n. 9
url http://www.repositorio.ufba.br/ri/handle/ri/7675
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1046/j.1365-3024.2001.00407.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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