Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13912 |
Resumo: | Texto completo: acesso restrito. p. 1406–1410 |
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Mello, Vivianne Barretto deCruz, Thomaz Rodrigues Porto daNuñez, Geila RibeiroSimões, Maria TerezaBraga, Hélio Jose VieiraAraújo, CésarCunha, Simone Muniz Carvalho Fernandes daSchinoni, Maria IsabelCruz, MarlaParaná, RaymundoMello, Vivianne Barretto deCruz, Thomaz Rodrigues Porto daNuñez, Geila RibeiroSimões, Maria TerezaBraga, Hélio Jose VieiraAraújo, CésarCunha, Simone Muniz Carvalho Fernandes daSchinoni, Maria IsabelCruz, MarlaParaná, Raymundo2013-11-26T13:07:53Z20060146-6615http://repositorio.ufba.br/ri/handle/ri/13912v. 78, n. 11Texto completo: acesso restrito. p. 1406–1410Patients with hepatitis C virus (HCV) infection present higher risk of developing type-2 diabetes mellitus (DM). However, the mechanism of this association and the role of antiviral treatment are still unclear. The objective of this study was to investigate the relationship between the use of peguilated interferon and the development of insulin resistance (IR) in these patients. Methods: HOMA index was evaluated in 30 HCV-infected patients just before and during the first 6 months of treatment with peguilated interferon plus ribavirin. Anthropometrical parameters and glucose/cholesterol profile were also monitored. Results: No changes in HOMA after 6 months of treatment were observed. Glucose levels decreased but not significantly (P = 0.059). Patients with higher HOMA index after 6 months of treatment also presented higher aminotransferase levels (P = 0.03), higher fat index on computed tomography (P = 0.011), longer time of exposure to the virus (P = 0.021), and a positive smoking history when compared to non-insulin resistant patients (P = 0.045). There was no influence of fibrosis stage on liver biopsy in the insulin-resistance development. Conclusions: No changes in the IR were observed after 6 months of treatment. Insulin resistance is related to the abdominal fat and anthropometrical parameters rather than to the antiviral treatment. J. 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| dc.title.pt_BR.fl_str_mv |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Medical Virology |
| title |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| spellingShingle |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin Mello, Vivianne Barretto de Interferon Peripheral insulin resistance Virus c hepatitis Diabetes mellitus |
| title_short |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| title_full |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| title_fullStr |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| title_full_unstemmed |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| title_sort |
Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin |
| author |
Mello, Vivianne Barretto de |
| author_facet |
Mello, Vivianne Barretto de Cruz, Thomaz Rodrigues Porto da Nuñez, Geila Ribeiro Simões, Maria Tereza Braga, Hélio Jose Vieira Araújo, César Cunha, Simone Muniz Carvalho Fernandes da Schinoni, Maria Isabel Cruz, Marla Paraná, Raymundo |
| author_role |
author |
| author2 |
Cruz, Thomaz Rodrigues Porto da Nuñez, Geila Ribeiro Simões, Maria Tereza Braga, Hélio Jose Vieira Araújo, César Cunha, Simone Muniz Carvalho Fernandes da Schinoni, Maria Isabel Cruz, Marla Paraná, Raymundo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mello, Vivianne Barretto de Cruz, Thomaz Rodrigues Porto da Nuñez, Geila Ribeiro Simões, Maria Tereza Braga, Hélio Jose Vieira Araújo, César Cunha, Simone Muniz Carvalho Fernandes da Schinoni, Maria Isabel Cruz, Marla Paraná, Raymundo Mello, Vivianne Barretto de Cruz, Thomaz Rodrigues Porto da Nuñez, Geila Ribeiro Simões, Maria Tereza Braga, Hélio Jose Vieira Araújo, César Cunha, Simone Muniz Carvalho Fernandes da Schinoni, Maria Isabel Cruz, Marla Paraná, Raymundo |
| dc.subject.por.fl_str_mv |
Interferon Peripheral insulin resistance Virus c hepatitis Diabetes mellitus |
| topic |
Interferon Peripheral insulin resistance Virus c hepatitis Diabetes mellitus |
| description |
Texto completo: acesso restrito. p. 1406–1410 |
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2006 |
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2006 |
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2013-11-26T13:07:53Z |
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0146-6615 |
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v. 78, n. 11 |
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0146-6615 v. 78, n. 11 |
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