Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients

Bibliographic Details
Main Author: Angelo, Ana Luiza Dias
Publication Date: 2007
Other Authors: Angelo, Camila Dias, Torres, Alex José Leite, Ramos, André Maurício Costa, Lima, Márcia, Martins Netto, Eduardo, Brites, Carlos
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/6702
Summary: p.466-470
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spelling Angelo, Ana Luiza DiasAngelo, Camila DiasTorres, Alex José LeiteRamos, André Maurício CostaLima, MárciaMartins Netto, EduardoBrites, CarlosAngelo, Ana Luiza DiasAngelo, Camila DiasTorres, Alex José LeiteRamos, André Maurício CostaLima, MárciaMartins Netto, EduardoBrites, Carlos2012-09-06T13:41:48Z2012-09-06T13:41:48Z2007-101413-8670http://www.repositorio.ufba.br/ri/handle/ri/6702v. 11, n. 5p.466-470This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 < 200 cells/mm3) and patients with CD4 < 350 cells/mm3 (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm3 (range: 4 to 2,531 cells/mm3). Mean TLC was 1,900 cells/mm3 (range: 300 to 6,200 cells/mm3). Using a threshold value of 1,000 cells/mm3 for TLC, the positive predictive value (PPV) was 77% for CD4 < 200 cells/mm3, but the sensitivity was only 29%, while the negative predictive value (NPV) was 88%, with 98% specificity. Similar findings were observed for CD4 count < 350. Using the same threshold value of 1,000 cells/mm3 for TLC, sensitivity was 14%, and specificity 99% (PPV= 94%; NPV=62%). In 70/1,510 (5%) of the samples the sum of CD4 and CD8 cell counts was greater than the TLC and in 27% (419/1,510) this sum was below 65% of the TLC. TLC has a high specificity to identify patients for prophylaxis, but a quite low sensitivity. It is not useful as an alternative to CD4+ T-cell counts as a marker in HIV-infected patients.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-06T13:41:48Z No. of bitstreams: 1 Angelo, Ana Luiza Dias.pdf: 87683 bytes, checksum: c251e32e82c4411b264006402ef2acc3 (MD5)Made available in DSpace on 2012-09-06T13:41:48Z (GMT). No. of bitstreams: 1 Angelo, Ana Luiza Dias.pdf: 87683 bytes, checksum: c251e32e82c4411b264006402ef2acc3 (MD5) Previous issue date: 2007-10SalvadorThe Brazilian Journal of Infectious Diseases and Contexto Publishinghttp://dx.doi.org/10.1590/S1413-86702007000500005reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALymphocyte countsCD4 countsAIDSEvaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patientsBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALAngelo, Ana Luiza Dias.pdfAngelo, Ana Luiza Dias.pdfapplication/pdf87683https://repositorio.ufba.br/bitstream/ri/6702/1/Angelo%2c%20Ana%20Luiza%20Dias.pdfc251e32e82c4411b264006402ef2acc3MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6702/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTAngelo, Ana Luiza Dias.pdf.txtAngelo, Ana Luiza Dias.pdf.txtExtracted texttext/plain23552https://repositorio.ufba.br/bitstream/ri/6702/3/Angelo%2c%20Ana%20Luiza%20Dias.pdf.txt916bf9bc0234dd6e2cd5c32d9aee91e9MD53ri/67022022-07-05 14:03:11.229oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestrepositorio@ufba.bropendoar:19322022-07-05T17:03:11Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
spellingShingle Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
Angelo, Ana Luiza Dias
Lymphocyte counts
CD4 counts
AIDS
title_short Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
title_full Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
title_fullStr Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
title_full_unstemmed Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
title_sort Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
author Angelo, Ana Luiza Dias
author_facet Angelo, Ana Luiza Dias
Angelo, Camila Dias
Torres, Alex José Leite
Ramos, André Maurício Costa
Lima, Márcia
Martins Netto, Eduardo
Brites, Carlos
author_role author
author2 Angelo, Camila Dias
Torres, Alex José Leite
Ramos, André Maurício Costa
Lima, Márcia
Martins Netto, Eduardo
Brites, Carlos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Angelo, Ana Luiza Dias
Angelo, Camila Dias
Torres, Alex José Leite
Ramos, André Maurício Costa
Lima, Márcia
Martins Netto, Eduardo
Brites, Carlos
Angelo, Ana Luiza Dias
Angelo, Camila Dias
Torres, Alex José Leite
Ramos, André Maurício Costa
Lima, Márcia
Martins Netto, Eduardo
Brites, Carlos
dc.subject.por.fl_str_mv Lymphocyte counts
CD4 counts
AIDS
topic Lymphocyte counts
CD4 counts
AIDS
description p.466-470
publishDate 2007
dc.date.issued.fl_str_mv 2007-10
dc.date.accessioned.fl_str_mv 2012-09-06T13:41:48Z
dc.date.available.fl_str_mv 2012-09-06T13:41:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6702
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 11, n. 5
identifier_str_mv 1413-8670
v. 11, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/6702
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702007000500005
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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