Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes

• Main Author: Giongo J.L.
• Publication Date: 2017
• Other Authors: Vaucher R.A., Da Silva A.S.*, Oliveira C.B., de Mattos C.B., Baldissera M.D., Sagrillo M.R., Monteiro S.G., Custodio D.L., Souza de Matos M., Sampaio P.T., Teixeira H.F., Koester L.S., da Veiga Junior V.F.
• Format: Article
• Language: eng
• Source: Repositório Institucional da Udesc
• Download full: https://repositorio.udesc.br/handle/UDESC/7092

© 2016 Elsevier LtdAniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi.