HIV/HBV COINFECTION: ASSOCIATED FACTORS WITH HBV FUNCTIONAL CURE

• Main Author: Teixeira Amorim, Laila Maria
• Publication Date: 2025
• Other Authors: Fernandes Távora, Lara Gurgel
• Format: Article
• Language: por
• Source: Cadernos ESP (Online)
• Download full: https://cadernos.esp.ce.gov.br/index.php/cadernos/article/view/2273
• topic: HIV; Vírus da Hepatite B; Terapia Antirretroviral de Alta Atividade; Antígenos de Superfície da Hepatite B; VIH; Virus de la Hepatitis B; Terapia Antirretroviral Altamente Activa; Antígenos de Superficie de la Hepatitis B; HIV; Hepatitis B Virus; Highly Active Antiretroviral Therapy; Hepatitis B Surface Antigens

HIV research has remained frequent since its discovery. HIV/HBV co-infection is highly significant as it impacts on the natural history of chronic HBV infection, increasing morbidity and mortality. Objective: To identify the prevalence of functional cure in patients with HIV/HBV coinfection and the possible factors associated with this cure. Method: This is a retrospective cohort study conducted between July 2023 and August 2024 in two healthcare centers in Fortaleza. Results: Of the 175 coinfected patients included in the study, only 146 had access to control HBsAg. In the comparative analysis between the two groups, factors such as the absence of positive HBeAg and lack of detection of HBV-DNA were statistically significant for HBsAg clearance. Conclusion: These results suggest that proper control of HBV, particularly in patients with negative HBeAg, is associated with a higher prevalence of functional cure.