Prevalence of HTLV-1 and HTLV-2 in patients infected with HIV from a Reference Center of São Paulo

• Main Author: Caterino de Araujo, Adele
• Publication Date: 2014
• Other Authors: Barreto-Damião, Carlos Henrique, Almeida, Alexandre, Tavares Sacchi, Cláudio, Gonçalves, Maria Gisele, Okuyama Fukasawa, Lucila, Marques Salgado, Maristela, de Macedo Brígido, Luis Fernando, Takenori Higa, Fábio, Rodrigues Campos, Karoline, Portes Ozório Coelho, Luana, Brito de Santana, Marcela, Cavalheiro Magri, Mariana, Miyuki Oshiro, Telma, Jamal, Leda Fátima, Jorge, Maria de Fátima, Rocha Mello, Maria Lúcia, Santos de Oliveira, Risia Cristina, Kuen Alencar, Wong
• Format: Article
• Language: por
• Source: BEPA. Boletim epidemiológico paulista (Online)
• Download full: https://periodicos.saude.sp.gov.br/BEPA182/article/view/38196
• topic: HTLV-1; HTLV-2; HIV; Coinfecção; Prevalência; Categorias de risco; HTLV-1; HTLV-2; HIV; Coinfection; Prevalence; Risk factors

 The HTLV-1, HTLV-2, and HIV share the same routes of virus transmission and high   prevalence rates of HIV/HTLV coinfections have been detected in AIDS patients from Sao   Paulo, during the 1990s, and were linked to injection drug use (IDU). The present study   searched for the current prevalence and risk factors for HIV/HTLV coinfections in patients   attended at AIDS Reference and Training Center in São Paulo (CRT DST/Aids SP). Blood   samples of 1,608 patients that were enrolled in the study were sent to Instituto Adolfo Lutz   and analyzed for the presence of HTLV-1/2 specific antibodies by enzyme immunoassay   and Western Blot (WB), and for pol proviral DNA segments of HTLV-1 and HTLV-2 by   “in house” real-time PCR. The results obtained disclosed 51 reagents sera at screening.   By WB analysis, 23 (1.43%) confirmed HTLV-1 infection, 12 (0.75%) HTLV-2, and 6   (0.37%) HTLV not typed. The PCR confirmed one more case of HTLV-1 (total 1.49%) and   five of HTLV-2 (total 1.06%). Associations between HIV/HTLV coinfections and female   gender (p=0.0027), black/pardum color/race (p=0.0332), infection with HBV (p=0.0019),   HCV and IDU (p<0.0000) were detected. The real time PCR confirmed cases of HTLV not   typed and indeterminate on WB analysis, and could be used as the first confirmatory assay   followed by WB. The low prevalence rates of HIV/HTLV coinfections detected in the   present study could be related to changes in the exposure to HIV and cocaine inhalation/   smoking drug usage instead of injection at the present moment.