Unusual combination of gestational trophoblastic neoplasias: case report

• Main Author: Ramilo,Irina Dulce Tapadinhas Matos
• Publication Date: 2014
• Other Authors: Mendinhos,Gustavo Martins, Igreja,Fernando Antônio Ferreira da, Aleluia,Maria Clara Morais, Nogueira,Rosete Maria Amorim Novais, Gomes,Fernando Manuel Ribeiro, Pereira,José Manuel Silva
• Format: Report
• Language: eng
• Source: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500375
• topic: choriocarcinoma; gestational; trophoblast; neoplasm; chemotherapy

Gestational trophoblastic disease comprises a heterogeneous group of lesions arising from abnormal proliferation of trophoblastic cells. An elevation of human chorionic gonadotropin after evacuation of a molar pregnancy should suggest the hypothesis of a persistent gestational trophoblastic neoplasia. We present a rare case of coexistence of choriocarcinoma and placental-site trophoblastic tumor in the same tumor, whose diagnosis was made based on the correlation of morphological, microscopic and immunocytochemical studies, due to the difficulty in diagnosing these mixed tumors based on conventional histology only.