The influence of CD 4+t cells, hiv disease stage and zidovudine on hiv isolation in Bahia, Brazil

• Main Author: Brites,Carlos
• Publication Date: 1996
• Other Authors: Pedroso,Célia, Silva,Nanci, Johnson Jr,Warren D, Badaró,Roberto
• Format: Article
• Language: eng
• Source: Revista da Sociedade Brasileira de Medicina Tropical
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821996000100002
• topic: HIV; P24; Viral isolation; Brazil; CD4+ Tlymphocytes

HIV-l isolation was attempted on 72 individuais, including persons with knoum HIV infection and five without proven HIV infection but with indeterminate Western blot patterns, as well as on low-risk HIV seronegative persons. The ahility to detect HIV- 1 frorn culture supernatant by p24 antigen capture assay was evaluated by segregating patients by absolute CD4+ cell counts, clinicai stage of disease, p24 antigenemia and zidovudine use. The likelihood of a p24 positive HIV culture was highest among patients with CD4+ T-cell counts below 200/ul and patients with advanced clinical disease. Use of zidovudine did not affect the rate ofHIV positwity in cultures.