Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease

• Main Author: Zhong,Chen
• Publication Date: 2009
• Other Authors: Quanzhong,Yin, Genshan,Ma, Hua,Zhang, Ruolong,Zheng, Jiahong,Wang, Chunheng,Gao
• Format: Article
• Language: eng
• Source: Genetics and Molecular Biology
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
• topic: premature coronary artery disease; myeloperoxidase; protective genetic polymorphism

We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.