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The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

Bibliographic Details
Main Author: Yilmaz,Ercan
Publication Date: 2018
Other Authors: Melekoglu,Rauf, Ciftci,Osman, Eraslan,Sevil, Cetin,Asli, Basak,Nese
Format: Article
Language: eng
Source: Acta Cirúrgica Brasileira (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000600499
Summary: Abstract Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
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spelling The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in ratsCyclophosphamideCurcuminCapsaicinAntioxidantRats.Abstract Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000600499Acta Cirúrgica Brasileira v.33 n.6 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180060000004info:eu-repo/semantics/openAccessYilmaz,ErcanMelekoglu,RaufCiftci,OsmanEraslan,SevilCetin,AsliBasak,Neseeng2018-11-22T00:00:00Zoai:scielo:S0102-86502018000600499Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-11-22T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
title The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
spellingShingle The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
Yilmaz,Ercan
Cyclophosphamide
Curcumin
Capsaicin
Antioxidant
Rats.
title_short The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
title_full The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
title_fullStr The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
title_full_unstemmed The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
title_sort The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
author Yilmaz,Ercan
author_facet Yilmaz,Ercan
Melekoglu,Rauf
Ciftci,Osman
Eraslan,Sevil
Cetin,Asli
Basak,Nese
author_role author
author2 Melekoglu,Rauf
Ciftci,Osman
Eraslan,Sevil
Cetin,Asli
Basak,Nese
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Yilmaz,Ercan
Melekoglu,Rauf
Ciftci,Osman
Eraslan,Sevil
Cetin,Asli
Basak,Nese
dc.subject.por.fl_str_mv Cyclophosphamide
Curcumin
Capsaicin
Antioxidant
Rats.
topic Cyclophosphamide
Curcumin
Capsaicin
Antioxidant
Rats.
description Abstract Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000600499
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000600499
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020180060000004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.33 n.6 2018
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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