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Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture

Bibliographic Details
Main Author: Loureiro, Ana Miguel da Silva
Publication Date: 2021
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10773/30980
Summary: The transition from the second to the third dimension is crucial to improve the reliability and predictive ability of cell-based assays, motivating the development of in vitro systems that could recapitulate the physiological cellular microenvironment. Proteins naturally occurring in the human body have been attracting attention as biomaterials for scaffold fabrication, due to their biochemical similarity with native tissues and potential allogenic source. In this context, METATISSUE has developed a novel photopolymerizable hydrogel based on human platelet lysates (PL) proteins to improve cell adhesion.
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spelling Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture3D cell cultureHydrogelsPlatelet lysatesAqueous biphasic systemsThree-phase partitioningAlbumin removalProteinsThe transition from the second to the third dimension is crucial to improve the reliability and predictive ability of cell-based assays, motivating the development of in vitro systems that could recapitulate the physiological cellular microenvironment. Proteins naturally occurring in the human body have been attracting attention as biomaterials for scaffold fabrication, due to their biochemical similarity with native tissues and potential allogenic source. In this context, METATISSUE has developed a novel photopolymerizable hydrogel based on human platelet lysates (PL) proteins to improve cell adhesion.A transição da segunda para a terceira dimensão é crucial para melhorar a fiabilidade e a capacidade de previsão dos ensaios celulares, motivando o desenvolvimento de plataformas capazes de recapitular o microambiente celular fisiológico in vitro. As proteínas naturalmente presentes no corpo humano têm atraído atenção como biomateriais para o fabrico de plataformas, devido à sua semelhança bioquímica com os tecidos nativos e a sua potencial origem alogénica. Neste contexto, a METATISSUE desenvolveu um novo hidrogel fotopolimerizável baseado em proteínas de lisados de plaquetas humanas (PL) para melhorar a adesão celular.2026-08-19T00:00:00Z2021-02-19T00:00:00Z2021-02-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10773/30980engLoureiro, Ana Miguel da Silvainfo:eu-repo/semantics/embargoedAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-10-28T01:45:39Zoai:ria.ua.pt:10773/30980Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:11:17.427460Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
title Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
spellingShingle Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
Loureiro, Ana Miguel da Silva
3D cell culture
Hydrogels
Platelet lysates
Aqueous biphasic systems
Three-phase partitioning
Albumin removal
Proteins
title_short Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
title_full Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
title_fullStr Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
title_full_unstemmed Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
title_sort Removal of albumin from platelet lysates for the fabrication of hydrogels for 3D cell culture
author Loureiro, Ana Miguel da Silva
author_facet Loureiro, Ana Miguel da Silva
author_role author
dc.contributor.author.fl_str_mv Loureiro, Ana Miguel da Silva
dc.subject.por.fl_str_mv 3D cell culture
Hydrogels
Platelet lysates
Aqueous biphasic systems
Three-phase partitioning
Albumin removal
Proteins
topic 3D cell culture
Hydrogels
Platelet lysates
Aqueous biphasic systems
Three-phase partitioning
Albumin removal
Proteins
description The transition from the second to the third dimension is crucial to improve the reliability and predictive ability of cell-based assays, motivating the development of in vitro systems that could recapitulate the physiological cellular microenvironment. Proteins naturally occurring in the human body have been attracting attention as biomaterials for scaffold fabrication, due to their biochemical similarity with native tissues and potential allogenic source. In this context, METATISSUE has developed a novel photopolymerizable hydrogel based on human platelet lysates (PL) proteins to improve cell adhesion.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-19T00:00:00Z
2021-02-19
2026-08-19T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/30980
url http://hdl.handle.net/10773/30980
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594373868093440

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