A Structural View of miRNA Biogenesis and Function

Bibliographic Details
Main Author: Leitão, Ana Lúcia
Publication Date: 2022
Other Authors: Enguita, Francisco J.
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/142791
Summary: PTDC-MED-GEN-29389-2017
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling A Structural View of miRNA Biogenesis and FunctionArgonauteBiogenesisCryo-electron microscopyDGCR8DicerDroshaExportin-5MicroRNANucleaseRISCStructural biologyX-ray crystallographyBiochemistryMolecular BiologyGeneticsSDG 3 - Good Health and Well-beingPTDC-MED-GEN-29389-2017Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as posttranscriptional regulators of gene expression. Since their discovery in 1993, they have been the subject of deep study due to their involvement in many important biological processes. Compared with other ncRNAs, miRNAs are generated from devoted transcriptional units which are processed by a specific set of endonucleases. The contribution of structural biology methods for understanding miRNA biogenesis and function has been essential for the dissection of their roles in cell biology and human disease. In this review, we summarize the application of structural biology for the characterization of the molecular players involved in miRNA biogenesis (processors and effectors), starting from the X-ray crystallography methods to the more recent cryo-electron microscopy protocols.MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosDCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)RUNLeitão, Ana LúciaEnguita, Francisco J.2022-08-02T22:24:16Z2022-01-182022-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other18application/pdfhttp://hdl.handle.net/10362/142791eng2311-553XPURE: 42479958https://doi.org/10.3390/ncrna8010010info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:04:12Zoai:run.unl.pt:10362/142791Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:34:45.197507Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv A Structural View of miRNA Biogenesis and Function
title A Structural View of miRNA Biogenesis and Function
spellingShingle A Structural View of miRNA Biogenesis and Function
Leitão, Ana Lúcia
Argonaute
Biogenesis
Cryo-electron microscopy
DGCR8
Dicer
Drosha
Exportin-5
MicroRNA
Nuclease
RISC
Structural biology
X-ray crystallography
Biochemistry
Molecular Biology
Genetics
SDG 3 - Good Health and Well-being
title_short A Structural View of miRNA Biogenesis and Function
title_full A Structural View of miRNA Biogenesis and Function
title_fullStr A Structural View of miRNA Biogenesis and Function
title_full_unstemmed A Structural View of miRNA Biogenesis and Function
title_sort A Structural View of miRNA Biogenesis and Function
author Leitão, Ana Lúcia
author_facet Leitão, Ana Lúcia
Enguita, Francisco J.
author_role author
author2 Enguita, Francisco J.
author2_role author
dc.contributor.none.fl_str_mv MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)
RUN
dc.contributor.author.fl_str_mv Leitão, Ana Lúcia
Enguita, Francisco J.
dc.subject.por.fl_str_mv Argonaute
Biogenesis
Cryo-electron microscopy
DGCR8
Dicer
Drosha
Exportin-5
MicroRNA
Nuclease
RISC
Structural biology
X-ray crystallography
Biochemistry
Molecular Biology
Genetics
SDG 3 - Good Health and Well-being
topic Argonaute
Biogenesis
Cryo-electron microscopy
DGCR8
Dicer
Drosha
Exportin-5
MicroRNA
Nuclease
RISC
Structural biology
X-ray crystallography
Biochemistry
Molecular Biology
Genetics
SDG 3 - Good Health and Well-being
description PTDC-MED-GEN-29389-2017
publishDate 2022
dc.date.none.fl_str_mv 2022-08-02T22:24:16Z
2022-01-18
2022-01-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142791
url http://hdl.handle.net/10362/142791
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2311-553X
PURE: 42479958
https://doi.org/10.3390/ncrna8010010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596809449046016

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