Preditores de resposta à terapêutica de ressincronização cardíaca
| Autor(a) principal: | |
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| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10362/148250 |
Resumo: | Funding: This work was supported by research grant PTDC/DES/120249/2010 from the Foundation for Science and Technology (FCT). |
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Preditores de resposta à terapêutica de ressincronização cardíacaPredictors of response to cardiac resynchronization therapyA prospective cohort studyestudo cohort prospetivoCardiac resynchronization therapyChronic heart failurePredictorsResponderCardiology and Cardiovascular MedicineFunding: This work was supported by research grant PTDC/DES/120249/2010 from the Foundation for Science and Technology (FCT).Introduction Cardiac resynchronization therapy (CRT) has modified the prognosis of chronic heart failure (HF) with left ventricular systolic dysfunction. However, 30% of patients do not have a favorable response. The big question is how to determine predictors of response. Aims To identify baseline characteristics that might influence echocardiographic response to CRT. Methods and Results We performed a prospective single-center hospital-based cohort study of consecutive HF patients selected to CRT (NYHA class II-IV, left ventricular ejection fraction (LVEF) <35% and QRS complex ≥120 ms). Responders were defined as those with a ≥5% absolute increase in LVEF at six months. Clinical, electrocardiographic, laboratory, echocardiographic, autonomic, endothelial and cardiopulmonary function parameters were assessed before CRT device implantation. Logistic regression models were used. Seventy-nine patients were included, 54 male (68.4%), age 68.1 years (standard deviation 10.2), 19 with ischemic etiology (24%). At six months, 51 patients (64.6%) were considered responders. Although by univariate analysis baseline tricuspid annular plane systolic excursion (TAPSE) and serum creatinine were significantly different in responders, on multivariate analysis only TAPSE was independently associated with response, with higher values predicting a positive response to CRT (OR=1.13; 95% CI: 1.02-1.26; p=0.020). TAPSE ≥15 mm was strongly associated with response, and TAPSE <15 mm with non-response (p=0.005). Responders had no TAPSE values below 10 mm. Conclusion From a range of clinical and technical baseline characteristics, multivariate analysis only identified TAPSE as an independent predictor of CRT response, with TAPSE <15 mm associated with non-response. This study highlights the importance of right ventricular dysfunction in CRT response. ClinicalTrials.gov identifier: NCT02413151.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAbreu, AnaOliveira, MárioSilva Cunha, PedroSanta Clara, HelenaSantos, VanessaPortugal, GuilhermeRio, PedroSoares, RuiMoura Branco, LuísaAlves, MartaPapoila, Ana LuísaFerreira, RuiMota Carmo, M2023-01-27T22:09:24Z2017-06-012017-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/148250por0870-2551PURE: 3157209https://doi.org/10.1016/j.repc.2016.10.010info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-10-21T01:36:33Zoai:run.unl.pt:10362/148250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:58.096241Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Preditores de resposta à terapêutica de ressincronização cardíaca Predictors of response to cardiac resynchronization therapyA prospective cohort study estudo cohort prospetivo |
| title |
Preditores de resposta à terapêutica de ressincronização cardíaca |
| spellingShingle |
Preditores de resposta à terapêutica de ressincronização cardíaca Abreu, Ana Cardiac resynchronization therapy Chronic heart failure Predictors Responder Cardiology and Cardiovascular Medicine |
| title_short |
Preditores de resposta à terapêutica de ressincronização cardíaca |
| title_full |
Preditores de resposta à terapêutica de ressincronização cardíaca |
| title_fullStr |
Preditores de resposta à terapêutica de ressincronização cardíaca |
| title_full_unstemmed |
Preditores de resposta à terapêutica de ressincronização cardíaca |
| title_sort |
Preditores de resposta à terapêutica de ressincronização cardíaca |
| author |
Abreu, Ana |
| author_facet |
Abreu, Ana Oliveira, Mário Silva Cunha, Pedro Santa Clara, Helena Santos, Vanessa Portugal, Guilherme Rio, Pedro Soares, Rui Moura Branco, Luísa Alves, Marta Papoila, Ana Luísa Ferreira, Rui Mota Carmo, M |
| author_role |
author |
| author2 |
Oliveira, Mário Silva Cunha, Pedro Santa Clara, Helena Santos, Vanessa Portugal, Guilherme Rio, Pedro Soares, Rui Moura Branco, Luísa Alves, Marta Papoila, Ana Luísa Ferreira, Rui Mota Carmo, M |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Abreu, Ana Oliveira, Mário Silva Cunha, Pedro Santa Clara, Helena Santos, Vanessa Portugal, Guilherme Rio, Pedro Soares, Rui Moura Branco, Luísa Alves, Marta Papoila, Ana Luísa Ferreira, Rui Mota Carmo, M |
| dc.subject.por.fl_str_mv |
Cardiac resynchronization therapy Chronic heart failure Predictors Responder Cardiology and Cardiovascular Medicine |
| topic |
Cardiac resynchronization therapy Chronic heart failure Predictors Responder Cardiology and Cardiovascular Medicine |
| description |
Funding: This work was supported by research grant PTDC/DES/120249/2010 from the Foundation for Science and Technology (FCT). |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-06-01 2017-06-01T00:00:00Z 2023-01-27T22:09:24Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10362/148250 |
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http://hdl.handle.net/10362/148250 |
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por |
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por |
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0870-2551 PURE: 3157209 https://doi.org/10.1016/j.repc.2016.10.010 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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9 application/pdf |
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