Apparent diffusion coefficient in the analysis of prostate cancer: determination of optimal b-value pair to differentiate normal from malignant tissue

• Main Author: Adubeiro, Nuno
• Publication Date: 2018
• Other Authors: Nogueira, Maria Luísa, Nunes, Rita G., Ferreira, Hugo Alexandre, Ribeiro, Eduardo, La Fuente, José Maria Ferreira
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.22/14138
• topic: Diffusion weighted imaging; Diffusion Magnetic Resonance Imaging; Prostate; Prostatic Neoplasms

Purpose Determining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues. Methods Forty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500 s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC) > 95%. Results 15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000 s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89 × 10–3 mm2/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%. Conclusions The best b-value pair was b = 50, 2000 s/mm2.