Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization

Bibliographic Details
Main Author: Dias, Rolando
Publication Date: 2016
Other Authors: Costa, Mário Rui
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10198/13012
Summary: The grafting of functional brushes on the surface of molecularly imprinted polymer (MIP). particles hás been explored in the last few years to synthesize materiais combining high molecular recognition capabilities and stimulation triggered by changes in the surrounding environment [1, 2]. In the present work, MIP particles for 5-fluorouracil (a drug used in câncer treatment) were produced by precipitation polymerization in acetonitrile, using either MAA or HEMA as imprinting fünctional monomers, and m the presence of different kinds of RAFT agents. In a second step, taking advantage of the RAFT groups present in the surface of the particles, different kinds of fiinctional polymer brushes were grafted on the MIPs considering a "grafting from" process in the presence of a RAFT agent.
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spelling Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerizationMolecular imprintingRAFT polymerizationSurface graftingThe grafting of functional brushes on the surface of molecularly imprinted polymer (MIP). particles hás been explored in the last few years to synthesize materiais combining high molecular recognition capabilities and stimulation triggered by changes in the surrounding environment [1, 2]. In the present work, MIP particles for 5-fluorouracil (a drug used in câncer treatment) were produced by precipitation polymerization in acetonitrile, using either MAA or HEMA as imprinting fünctional monomers, and m the presence of different kinds of RAFT agents. In a second step, taking advantage of the RAFT groups present in the surface of the particles, different kinds of fiinctional polymer brushes were grafted on the MIPs considering a "grafting from" process in the presence of a RAFT agent.This work was financially supported by: Project POCI-01-0145-FEDER-006984 – Associated Laboratory LSRE/LCM funded by FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI).Biblioteca Digital do IPBDias, RolandoCosta, Mário Rui2016-06-23T15:48:00Z20162016-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10198/13012engOliveira, Daniela; Dias, Rolando; Costa, Mário (2016). Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization. In 12th International Workshop on Polymer Reaction Engineering. University of Hamburg, Germanyinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-25T12:03:31Zoai:bibliotecadigital.ipb.pt:10198/13012Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T11:29:32.221014Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
title Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
spellingShingle Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
Dias, Rolando
Molecular imprinting
RAFT polymerization
Surface grafting
title_short Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
title_full Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
title_fullStr Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
title_full_unstemmed Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
title_sort Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization
author Dias, Rolando
author_facet Dias, Rolando
Costa, Mário Rui
author_role author
author2 Costa, Mário Rui
author2_role author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Dias, Rolando
Costa, Mário Rui
dc.subject.por.fl_str_mv Molecular imprinting
RAFT polymerization
Surface grafting
topic Molecular imprinting
RAFT polymerization
Surface grafting
description The grafting of functional brushes on the surface of molecularly imprinted polymer (MIP). particles hás been explored in the last few years to synthesize materiais combining high molecular recognition capabilities and stimulation triggered by changes in the surrounding environment [1, 2]. In the present work, MIP particles for 5-fluorouracil (a drug used in câncer treatment) were produced by precipitation polymerization in acetonitrile, using either MAA or HEMA as imprinting fünctional monomers, and m the presence of different kinds of RAFT agents. In a second step, taking advantage of the RAFT groups present in the surface of the particles, different kinds of fiinctional polymer brushes were grafted on the MIPs considering a "grafting from" process in the presence of a RAFT agent.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-23T15:48:00Z
2016
2016-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/13012
url http://hdl.handle.net/10198/13012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira, Daniela; Dias, Rolando; Costa, Mário (2016). Grafting of functional brushes on the surface of 5-Fluorouracil molecularly imprinted polymer particles through RAFT polymerization. In 12th International Workshop on Polymer Reaction Engineering. University of Hamburg, Germany
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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