COVID-19 vaccine effectiveness among healthcare workers
| Main Author: | |
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| Publication Date: | 2023 |
| Other Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/155193 |
Summary: | Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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COVID-19 vaccine effectiveness among healthcare workersa hospital-based cohort studyCOVID-19epidemiologyoccupational & industrial medicinepublic healthMedicine(all)SDG 3 - Good Health and Well-beingPublisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: Healthcare workers (HCWs) were the first to be prioritised for COVID-19 vaccination. This study aims to estimate the COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 symptomatic infection among HCWs in Portuguese hospitals. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: We analysed data from HCWs (all professional categories) from three central hospitals: one in the Lisbon and Tagus Valley region and two in the central region of mainland Portugal, between December 2020 and March 2022. VE against symptomatic SARS-CoV-2 infection was estimated as one minus the confounder adjusted HRs by Cox models considering age group, sex, self-reported chronic disease and occupational exposure to patients diagnosed with COVID-19 as adjustment variables. RESULTS: During the 15 months of follow-up, the 3034 HCWs contributed a total of 3054 person-years at risk, and 581 SARS-CoV-2 events occurred. Most participants were already vaccinated with a booster dose (n=2653, 87%), some are vaccinated with only the primary scheme (n=369, 12.6%) and a few remained unvaccinated (n=12, 0.4%) at the end of the study period. VE against symptomatic infection was 63.6% (95% CI 22.6% to 82.9%) for HCWs vaccinated with two doses and 55.9% (95% CI -1.3% to 80.8%) for HCWs vaccinated with one booster dose. Point estimate VE was higher for individuals with two doses taken between 14 days and 98 days (VE=71.9%; 95% CI 32.3% to 88.3%). CONCLUSION: This cohort study found a high COVID-19 VE against symptomatic SARS-CoV-2 infection in Portuguese HCWs after vaccination with one booster dose, even after Omicron variant occurrence. The small sample size, the high vaccine coverage, the very low number of unvaccinated individuals and the few events observed during the study period contributed to the low precision of the estimates.Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNGaio, VâniaSantos, Ana JoãoAmaral, PalmiraFaro Viana, JoãoAntunes, IsabelPacheco, VâniaPaiva, ArturPinto Leite, PedroAntunes Gonçalves, LígiaAraújo, LucíliaSilva, AdrianaDias, CarlosKislaya, IrinaNunes, BaltazarMachado, Ausenda2023-07-12T22:20:33Z2023-05-022023-05-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/155193eng2044-6055PURE: 66125358https://doi.org/10.1136/bmjopen-2022-068996info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:12:53Zoai:run.unl.pt:10362/155193Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:43:29.107310Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
COVID-19 vaccine effectiveness among healthcare workers a hospital-based cohort study |
| title |
COVID-19 vaccine effectiveness among healthcare workers |
| spellingShingle |
COVID-19 vaccine effectiveness among healthcare workers Gaio, Vânia COVID-19 epidemiology occupational & industrial medicine public health Medicine(all) SDG 3 - Good Health and Well-being |
| title_short |
COVID-19 vaccine effectiveness among healthcare workers |
| title_full |
COVID-19 vaccine effectiveness among healthcare workers |
| title_fullStr |
COVID-19 vaccine effectiveness among healthcare workers |
| title_full_unstemmed |
COVID-19 vaccine effectiveness among healthcare workers |
| title_sort |
COVID-19 vaccine effectiveness among healthcare workers |
| author |
Gaio, Vânia |
| author_facet |
Gaio, Vânia Santos, Ana João Amaral, Palmira Faro Viana, João Antunes, Isabel Pacheco, Vânia Paiva, Artur Pinto Leite, Pedro Antunes Gonçalves, Lígia Araújo, Lucília Silva, Adriana Dias, Carlos Kislaya, Irina Nunes, Baltazar Machado, Ausenda |
| author_role |
author |
| author2 |
Santos, Ana João Amaral, Palmira Faro Viana, João Antunes, Isabel Pacheco, Vânia Paiva, Artur Pinto Leite, Pedro Antunes Gonçalves, Lígia Araújo, Lucília Silva, Adriana Dias, Carlos Kislaya, Irina Nunes, Baltazar Machado, Ausenda |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Comprehensive Health Research Centre (CHRC) - Pólo ENSP Centro de Investigação em Saúde Pública (CISP/PHRC) Escola Nacional de Saúde Pública (ENSP) RUN |
| dc.contributor.author.fl_str_mv |
Gaio, Vânia Santos, Ana João Amaral, Palmira Faro Viana, João Antunes, Isabel Pacheco, Vânia Paiva, Artur Pinto Leite, Pedro Antunes Gonçalves, Lígia Araújo, Lucília Silva, Adriana Dias, Carlos Kislaya, Irina Nunes, Baltazar Machado, Ausenda |
| dc.subject.por.fl_str_mv |
COVID-19 epidemiology occupational & industrial medicine public health Medicine(all) SDG 3 - Good Health and Well-being |
| topic |
COVID-19 epidemiology occupational & industrial medicine public health Medicine(all) SDG 3 - Good Health and Well-being |
| description |
Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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2023 |
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2023-07-12T22:20:33Z 2023-05-02 2023-05-02T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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http://hdl.handle.net/10362/155193 |
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eng |
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eng |
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2044-6055 PURE: 66125358 https://doi.org/10.1136/bmjopen-2022-068996 |
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