The resting-brain of obsessive-compulsive disorder

Bibliographic Details
Main Author: Moreira, Pedro Silva
Publication Date: 2019
Other Authors: Marques, Paulo, Magalhães, Ricardo, Esteves, Madalena, Sousa, Nuno, Soares, José Miguel, Morgado, Pedro
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/62408
Summary: Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.
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spelling The resting-brain of obsessive-compulsive disorderObsessive-compulsive disorderResting-state networksFMRIScience & TechnologyObsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.Pedro Silva Moreira was supported by the FCT fellowship grant with the number PDE/BDE/113601/2015 from the PhD-iHES program; Paulo Marques was funded by the Fundação Calouste Gulbenkian (Contract grant number: P-139977; project “Better mental health during ageing based on temporal prediction of individual brain ageing trajectories (TEMPO)”); Ricardo Magalhães was supported by the FCT fellowship grant with the number PDE/BDE/113604/2015 from the PhD-iHES program; Madalena Esteves was supported by the FCT fellowship grant with the number SFRH/BD/52291/2013 from the PhDOC program. The present work was supported by SwitchBox-FP7-HEALTH2010-grant 259772-2 and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER).ElsevierUniversidade do MinhoMoreira, Pedro SilvaMarques, PauloMagalhães, RicardoEsteves, MadalenaSousa, NunoSoares, José MiguelMorgado, Pedro2019-08-302019-08-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/62408eng0925-492710.1016/j.pscychresns.2019.06.00831279239info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T04:16:08Zoai:repositorium.sdum.uminho.pt:1822/62408Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:58:49.404701Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The resting-brain of obsessive-compulsive disorder
title The resting-brain of obsessive-compulsive disorder
spellingShingle The resting-brain of obsessive-compulsive disorder
Moreira, Pedro Silva
Obsessive-compulsive disorder
Resting-state networks
FMRI
Science & Technology
title_short The resting-brain of obsessive-compulsive disorder
title_full The resting-brain of obsessive-compulsive disorder
title_fullStr The resting-brain of obsessive-compulsive disorder
title_full_unstemmed The resting-brain of obsessive-compulsive disorder
title_sort The resting-brain of obsessive-compulsive disorder
author Moreira, Pedro Silva
author_facet Moreira, Pedro Silva
Marques, Paulo
Magalhães, Ricardo
Esteves, Madalena
Sousa, Nuno
Soares, José Miguel
Morgado, Pedro
author_role author
author2 Marques, Paulo
Magalhães, Ricardo
Esteves, Madalena
Sousa, Nuno
Soares, José Miguel
Morgado, Pedro
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Moreira, Pedro Silva
Marques, Paulo
Magalhães, Ricardo
Esteves, Madalena
Sousa, Nuno
Soares, José Miguel
Morgado, Pedro
dc.subject.por.fl_str_mv Obsessive-compulsive disorder
Resting-state networks
FMRI
Science & Technology
topic Obsessive-compulsive disorder
Resting-state networks
FMRI
Science & Technology
description Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-30
2019-08-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/62408
url https://hdl.handle.net/1822/62408
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0925-4927
10.1016/j.pscychresns.2019.06.008
31279239
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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