PSORIASIS IMMUNOPATHOGENESIS

Bibliographic Details
Main Author: Osório, Filipa
Publication Date: 2016
Other Authors: Magina, Sofia, Azevedo, Filomena
Format: Article
Language: por
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://doi.org/10.29021/spdv.69.1.631
Summary: Psoriasis is a common disease, whose treatment has evolved with new discoveries on its pathogenesis. Thus it becomes important to study the involved molecular and immune mechanisms to best understand current treatment and potential therapeutic targets. In this paper we aim to review current knowledge on psoriasis pathogenesis. We describe the proposed role for the immune system, the keratinocytes and the microvasculature. The immune system is currently considered the primary pathogenic modulator and we describe T lymphocytes and other cell types role, cytokines, chemokines and counterregulatory mechanisms. Known as a genetic and environmental disorder, we refer to associated genetic polymorphisms and the relation to the expression of microRNAs.
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spelling PSORIASIS IMMUNOPATHOGENESISIMUNOPATOGÉNESE DA PSORÍASEPsoriasisImmunopathogenesisGenetic polymorphismPsoríaseImunopatogénesePolimorfismo genéticoPsoriasis is a common disease, whose treatment has evolved with new discoveries on its pathogenesis. Thus it becomes important to study the involved molecular and immune mechanisms to best understand current treatment and potential therapeutic targets. In this paper we aim to review current knowledge on psoriasis pathogenesis. We describe the proposed role for the immune system, the keratinocytes and the microvasculature. The immune system is currently considered the primary pathogenic modulator and we describe T lymphocytes and other cell types role, cytokines, chemokines and counterregulatory mechanisms. Known as a genetic and environmental disorder, we refer to associated genetic polymorphisms and the relation to the expression of microRNAs.A psoríase é uma doença comum, cujo tratamento tem evoluído a par de novas descobertas sobre a sua patogénese. Assim torna-se importante o estudo dos mecanismos moleculares e imunológicos envolvidos com vista à melhor compreensão do tratamento actual e de potenciais alvos terapêuticos. Nesta publicação pretendemos rever o estado actual do conhecimento relativamente à patogénese da psoríase. Descrevese o papel proposto para o sistema imunológico, os queratinócitos e a microvasculatura. O sistema imunológico é presentemente considerado o modulador patogénico primário, descrevendo-se a função de linfócitos T e outros tipos celulares, citocinas, quimiocinas e mecanismos contra-reguladores. Tratando-se de um distúrbio de etiologia genética e ambiental, fazemos referência aos polimorfismos genéticos associados e à relação com a expressão de microRNAs.Sociedade Portuguesa de Dermatologia e Venereologia2016-11-23T00:00:00Zinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.69.1.631oai:ojs.revista.spdv.com.pt:article/631Journal of the Portuguese Society of Dermatology and Venereology; Vol 69 No 1 (2011): Janeiro - Março; 11-24Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 69 n. 1 (2011): Janeiro - Março; 11-242182-24092182-2395reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/631https://doi.org/10.29021/spdv.69.1.631https://revista.spdv.com.pt/index.php/spdv/article/view/631/439Osório, FilipaMagina, SofiaAzevedo, Filomenainfo:eu-repo/semantics/openAccess2022-10-06T12:34:59Zoai:ojs.revista.spdv.com.pt:article/631Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T10:31:12.061137Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv PSORIASIS IMMUNOPATHOGENESIS
IMUNOPATOGÉNESE DA PSORÍASE
title PSORIASIS IMMUNOPATHOGENESIS
spellingShingle PSORIASIS IMMUNOPATHOGENESIS
Osório, Filipa
Psoriasis
Immunopathogenesis
Genetic polymorphism
Psoríase
Imunopatogénese
Polimorfismo genético
title_short PSORIASIS IMMUNOPATHOGENESIS
title_full PSORIASIS IMMUNOPATHOGENESIS
title_fullStr PSORIASIS IMMUNOPATHOGENESIS
title_full_unstemmed PSORIASIS IMMUNOPATHOGENESIS
title_sort PSORIASIS IMMUNOPATHOGENESIS
author Osório, Filipa
author_facet Osório, Filipa
Magina, Sofia
Azevedo, Filomena
author_role author
author2 Magina, Sofia
Azevedo, Filomena
author2_role author
author
dc.contributor.author.fl_str_mv Osório, Filipa
Magina, Sofia
Azevedo, Filomena
dc.subject.por.fl_str_mv Psoriasis
Immunopathogenesis
Genetic polymorphism
Psoríase
Imunopatogénese
Polimorfismo genético
topic Psoriasis
Immunopathogenesis
Genetic polymorphism
Psoríase
Imunopatogénese
Polimorfismo genético
description Psoriasis is a common disease, whose treatment has evolved with new discoveries on its pathogenesis. Thus it becomes important to study the involved molecular and immune mechanisms to best understand current treatment and potential therapeutic targets. In this paper we aim to review current knowledge on psoriasis pathogenesis. We describe the proposed role for the immune system, the keratinocytes and the microvasculature. The immune system is currently considered the primary pathogenic modulator and we describe T lymphocytes and other cell types role, cytokines, chemokines and counterregulatory mechanisms. Known as a genetic and environmental disorder, we refer to associated genetic polymorphisms and the relation to the expression of microRNAs.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-23T00:00:00Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.69.1.631
oai:ojs.revista.spdv.com.pt:article/631
url https://doi.org/10.29021/spdv.69.1.631
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/631
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/631
https://doi.org/10.29021/spdv.69.1.631
https://revista.spdv.com.pt/index.php/spdv/article/view/631/439
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 69 No 1 (2011): Janeiro - Março; 11-24
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 69 n. 1 (2011): Janeiro - Março; 11-24
2182-2409
2182-2395
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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