Environmental assessment of cytotoxic drugs in healthcare settings
| Main Author: | |
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| Publication Date: | 2020 |
| Other Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/180858 |
Summary: | Funding No specific funding has been allocated for this proposed work. |
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Environmental assessment of cytotoxic drugs in healthcare settingsprotocol for a systematic review and meta-analysisCytotoxic drugsEnvironmental assessmentMeta-analysisSystematic reviewMedicine (miscellaneous)SDG 3 - Good Health and Well-beingFunding No specific funding has been allocated for this proposed work.Background: Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodology for a systematic review and meta-analysis that aims to systematically review the published literature and quantify the level of environmental contamination of healthcare settings with cytotoxic drugs. Methods: This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol-2015 (PRISMA-P) guidelines. Six electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, CINAHL, and EMBASE) will be searched with no restrictions on publication period. Eligible studies will be identified and data will be extracted using a predefined data extraction form by at least two independent reviewers following best practice. Eligible studies should report calculated or calculable estimates on the proportion of positive samples tested for cytotoxic drugs and/or estimates on the concentration of the cytotoxic drug(s) in the tested samples. Risk of bias (RoB) will be assessed by using the RoB in Studies estimating Prevalence of Exposure to Occupational risk factors (RoB-SPEO) tool, which developed by the World Health Organization (WHO) and International Labour Organization (ILO) for environmental and occupational health systematic reviews. The random-effects model will be used to perform meta-analyses. Discussion: Occupational exposure to cytotoxic drugs is associated with short- and long-term adverse health outcomes. Following this protocol, the review to be carried out will be the first to fill an evidence gap on the environmental contamination of healthcare settings with cytotoxic drugs. The findings of this review will help in the understanding of the risk of occupational exposure of healthcare workers to cytotoxic drugs and facilitate the identification of priority areas for specific interventions. Ethics and dissemination: The systematic review methodology does not require ethics approval due to the nature of the study design. The results of the systematic review will be published in a peer-reviewed journal and will be publicly available. Systematic review registration: PROSPERO CRD42020162780, dated July 14, 2020.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNAl Alawi, LailaSoteriades, Elpidoforos S.Paulo, Marilia SilvaÖstlundh, LindaGrivna, MichalAl Maskari, FatimaAl-Rifai, Rami H.2025-03-18T21:07:23Z2020-10-192020-10-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://hdl.handle.net/10362/180858eng2046-4053PURE: 26685204https://doi.org/10.1186/s13643-020-01494-4info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-31T02:01:51Zoai:run.unl.pt:10362/180858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:42:07.167132Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Environmental assessment of cytotoxic drugs in healthcare settings protocol for a systematic review and meta-analysis |
| title |
Environmental assessment of cytotoxic drugs in healthcare settings |
| spellingShingle |
Environmental assessment of cytotoxic drugs in healthcare settings Al Alawi, Laila Cytotoxic drugs Environmental assessment Meta-analysis Systematic review Medicine (miscellaneous) SDG 3 - Good Health and Well-being |
| title_short |
Environmental assessment of cytotoxic drugs in healthcare settings |
| title_full |
Environmental assessment of cytotoxic drugs in healthcare settings |
| title_fullStr |
Environmental assessment of cytotoxic drugs in healthcare settings |
| title_full_unstemmed |
Environmental assessment of cytotoxic drugs in healthcare settings |
| title_sort |
Environmental assessment of cytotoxic drugs in healthcare settings |
| author |
Al Alawi, Laila |
| author_facet |
Al Alawi, Laila Soteriades, Elpidoforos S. Paulo, Marilia Silva Östlundh, Linda Grivna, Michal Al Maskari, Fatima Al-Rifai, Rami H. |
| author_role |
author |
| author2 |
Soteriades, Elpidoforos S. Paulo, Marilia Silva Östlundh, Linda Grivna, Michal Al Maskari, Fatima Al-Rifai, Rami H. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) RUN |
| dc.contributor.author.fl_str_mv |
Al Alawi, Laila Soteriades, Elpidoforos S. Paulo, Marilia Silva Östlundh, Linda Grivna, Michal Al Maskari, Fatima Al-Rifai, Rami H. |
| dc.subject.por.fl_str_mv |
Cytotoxic drugs Environmental assessment Meta-analysis Systematic review Medicine (miscellaneous) SDG 3 - Good Health and Well-being |
| topic |
Cytotoxic drugs Environmental assessment Meta-analysis Systematic review Medicine (miscellaneous) SDG 3 - Good Health and Well-being |
| description |
Funding No specific funding has been allocated for this proposed work. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-10-19 2020-10-19T00:00:00Z 2025-03-18T21:07:23Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/180858 |
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http://hdl.handle.net/10362/180858 |
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eng |
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eng |
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2046-4053 PURE: 26685204 https://doi.org/10.1186/s13643-020-01494-4 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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5 application/pdf |
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