DNA methylation biomarkers and myopia

Bibliographic Details
Main Author: Dong, Xing Xuan
Publication Date: 2024
Other Authors: Chen, Dong Ling, Chen, Hui Min, Li, Dan Lin, Hu, Dan Ning, Lanca, Carla, Grzybowski, Andrzej, Pan, Chen Wei
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/176002
Summary: Funding Information: This study was supported by the National Natural Science Foundation of China (82122059) and the National Key R&D Program of China (2021YFC2702100, 2021YFC2702103, and 2021YFC2702104). Publisher Copyright: © The Author(s) 2024.
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spelling DNA methylation biomarkers and myopiaa multi-omics study integrating GWAS, mQTL and eQTL dataBiomarkerDNA methylationMendelian randomizationMulti-omicsMyopiaMolecular BiologyGeneticsDevelopmental BiologyGenetics(clinical)SDG 3 - Good Health and Well-beingFunding Information: This study was supported by the National Natural Science Foundation of China (82122059) and the National Key R&D Program of China (2021YFC2702100, 2021YFC2702103, and 2021YFC2702104). Publisher Copyright: © The Author(s) 2024.Background: This study aimed to identify DNA methylation biomarkers associated with myopia using summary-data-based Mendelian randomization (SMR). Methods: A systematic search of the PubMed, Web of Science, Cochrane Library, and Embase databases was conducted up to March 27, 2024. SMR analyses were performed to integrate genome-wide association study (GWAS) with methylation quantitative trait loci (mQTL) and expression quantitative trait loci (eQTL) studies. The heterogeneity in the dependent instrument (HEIDI) test was utilized to distinguish pleiotropic associations from linkage disequilibrium. Results: The systematic review identified 26 DNA methylation biomarkers in five studies, with no overlap observed among those identified by different studies. After integrating GWAS with multi-omics data of mQTL and eQTL, six genes were significantly associated with myopia: PRMT6 (cg00944433 and cg15468180), SH3YL1 (cg03299269, cg11361895, and cg13354988), ZKSCAN4 (cg01192291), GATS (cg17830204), NPAT (cg04826772), and UBE2I (cg03545757 and cg08025960). Conclusions: We identified six methylation biomarkers associated with the risk of myopia that may be helpful to elucidate the etiology mechanisms of myopia. Further experimental validation studies are required to corroborate these findings.Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)RUNDong, Xing XuanChen, Dong LingChen, Hui MinLi, Dan LinHu, Dan NingLanca, CarlaGrzybowski, AndrzejPan, Chen Wei2024-11-28T23:12:57Z2024-122024-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/176002eng1868-7075PURE: 103946918https://doi.org/10.1186/s13148-024-01772-1info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-12-09T01:36:02Zoai:run.unl.pt:10362/176002Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:16:53.017795Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv DNA methylation biomarkers and myopia
a multi-omics study integrating GWAS, mQTL and eQTL data
title DNA methylation biomarkers and myopia
spellingShingle DNA methylation biomarkers and myopia
Dong, Xing Xuan
Biomarker
DNA methylation
Mendelian randomization
Multi-omics
Myopia
Molecular Biology
Genetics
Developmental Biology
Genetics(clinical)
SDG 3 - Good Health and Well-being
title_short DNA methylation biomarkers and myopia
title_full DNA methylation biomarkers and myopia
title_fullStr DNA methylation biomarkers and myopia
title_full_unstemmed DNA methylation biomarkers and myopia
title_sort DNA methylation biomarkers and myopia
author Dong, Xing Xuan
author_facet Dong, Xing Xuan
Chen, Dong Ling
Chen, Hui Min
Li, Dan Lin
Hu, Dan Ning
Lanca, Carla
Grzybowski, Andrzej
Pan, Chen Wei
author_role author
author2 Chen, Dong Ling
Chen, Hui Min
Li, Dan Lin
Hu, Dan Ning
Lanca, Carla
Grzybowski, Andrzej
Pan, Chen Wei
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Investigação em Saúde Pública (CISP/PHRC)
RUN
dc.contributor.author.fl_str_mv Dong, Xing Xuan
Chen, Dong Ling
Chen, Hui Min
Li, Dan Lin
Hu, Dan Ning
Lanca, Carla
Grzybowski, Andrzej
Pan, Chen Wei
dc.subject.por.fl_str_mv Biomarker
DNA methylation
Mendelian randomization
Multi-omics
Myopia
Molecular Biology
Genetics
Developmental Biology
Genetics(clinical)
SDG 3 - Good Health and Well-being
topic Biomarker
DNA methylation
Mendelian randomization
Multi-omics
Myopia
Molecular Biology
Genetics
Developmental Biology
Genetics(clinical)
SDG 3 - Good Health and Well-being
description Funding Information: This study was supported by the National Natural Science Foundation of China (82122059) and the National Key R&D Program of China (2021YFC2702100, 2021YFC2702103, and 2021YFC2702104). Publisher Copyright: © The Author(s) 2024.
publishDate 2024
dc.date.none.fl_str_mv 2024-11-28T23:12:57Z
2024-12
2024-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/176002
url http://hdl.handle.net/10362/176002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1868-7075
PURE: 103946918
https://doi.org/10.1186/s13148-024-01772-1
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833597989866700800

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