Multiparametric mobile sensing through luminescence thermometry for e-health

• Main Author: Silva, Sílvia Filipa Ventura da
• Publication Date: 2024
• Format: Master thesis
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10773/44779
• topic: Temperature; Luminescence thermometry; Mobile sensing; Smart labeling; E-health; M-health

The development of temperature sensors is pivotal in biomedical engineering, particularly within the realm of digital health (e-health), where integrating technology enhances healthcare delivery. Temperature is a critical physiological parameter that provides valuable insights into an individual's health, aiding in the diagnosis, treatment, and prevention of various medical conditions. Among temperature measurement techniques, luminescence thermometry stands out for its non-invasive nature and ease of use. Luminescence thermometry, leveraging the unique properties of luminescent materials, offers an intriguing approach to thermal sensing due to its sensitivity to temperature changes and compatibility with portable devices like smartphones. This innovation facilitates the development of advanced sensors for mobile monitoring, driving progress across multiple fields and improving quality of life. This dissertation investigates the potential of mobile luminescence thermometry using biocompatible materials such as carbon dots, which exhibit luminescence properties dependent on temperature. All samples demonstrated long-lived phosphorescence behavior (in the order of seconds), allowing the integration of emission acquisition time into the ratiometric temperature parameter (Δ). This multiparametric approach will optimize the thermal response and enhance sensitivity, creating distinct ratiometric parameters that can be found as a function of the temperature (T in ºC) and delay time (t in s), Δ(,). The emission mechanism is elucidated through thermally activated delayed phosphorescence (TADP). By modulating the TADP effect through different CD mixtures, we analyzed approximately 100 thermometric parameters within the 23 to 45 ºC range, revealing relatively high sensitivity values (7,9%∙°Cˉ¹). Utilizing a portable spectrophotometer and a mobile device for detection enhances the accessibility and versatility of luminescent thermometry. The integration of luminescence thermometry with mobile technology opens up new possibilities for continuous health monitoring and telemedicine.