Model systems, lipid rafts, and cell membranes

Bibliographic Details
Main Author: Simons, Kai
Publication Date: 2004
Other Authors: Vaz, Winchil L. C.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/11254
Summary: Views of how cell membranes are organized are presently changing. The lipid bilayer that constitutes these membranes is no longer understood to be a homogeneous fluid. Instead, lipid assemblies, termed rafts, have been introduced to provide fluid platforms that segregate membrane components and dynamically compartmentalize membranes. These assemblies are thought to be composed mainly of sphingolipids and cholesterol in the outer leaflet, somehow connected to domains of unknown composition in the inner leaflet. Specific classes of proteins are associated with the rafts. This review critically analyzes what is known of phase behavior and liquid-liquid immiscibility in model systems and compares these data with what is known of domain formation in cell membranes.
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spelling Model systems, lipid rafts, and cell membranesSphingolipidsCholesterolPhase immiscibilityDetergent resistanceMembrane proteinsViews of how cell membranes are organized are presently changing. The lipid bilayer that constitutes these membranes is no longer understood to be a homogeneous fluid. Instead, lipid assemblies, termed rafts, have been introduced to provide fluid platforms that segregate membrane components and dynamically compartmentalize membranes. These assemblies are thought to be composed mainly of sphingolipids and cholesterol in the outer leaflet, somehow connected to domains of unknown composition in the inner leaflet. Specific classes of proteins are associated with the rafts. This review critically analyzes what is known of phase behavior and liquid-liquid immiscibility in model systems and compares these data with what is known of domain formation in cell membranes.Annual Reviews2004-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/11254https://hdl.handle.net/10316/11254engAnnual review of biophysics and biomolecular structure. 33 (2004) 269-2951056-8700Simons, KaiVaz, Winchil L. C.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2020-05-25T13:16:27Zoai:estudogeral.uc.pt:10316/11254Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:24:20.472230Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Model systems, lipid rafts, and cell membranes
title Model systems, lipid rafts, and cell membranes
spellingShingle Model systems, lipid rafts, and cell membranes
Simons, Kai
Sphingolipids
Cholesterol
Phase immiscibility
Detergent resistance
Membrane proteins
title_short Model systems, lipid rafts, and cell membranes
title_full Model systems, lipid rafts, and cell membranes
title_fullStr Model systems, lipid rafts, and cell membranes
title_full_unstemmed Model systems, lipid rafts, and cell membranes
title_sort Model systems, lipid rafts, and cell membranes
author Simons, Kai
author_facet Simons, Kai
Vaz, Winchil L. C.
author_role author
author2 Vaz, Winchil L. C.
author2_role author
dc.contributor.author.fl_str_mv Simons, Kai
Vaz, Winchil L. C.
dc.subject.por.fl_str_mv Sphingolipids
Cholesterol
Phase immiscibility
Detergent resistance
Membrane proteins
topic Sphingolipids
Cholesterol
Phase immiscibility
Detergent resistance
Membrane proteins
description Views of how cell membranes are organized are presently changing. The lipid bilayer that constitutes these membranes is no longer understood to be a homogeneous fluid. Instead, lipid assemblies, termed rafts, have been introduced to provide fluid platforms that segregate membrane components and dynamically compartmentalize membranes. These assemblies are thought to be composed mainly of sphingolipids and cholesterol in the outer leaflet, somehow connected to domains of unknown composition in the inner leaflet. Specific classes of proteins are associated with the rafts. This review critically analyzes what is known of phase behavior and liquid-liquid immiscibility in model systems and compares these data with what is known of domain formation in cell membranes.
publishDate 2004
dc.date.none.fl_str_mv 2004-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/11254
https://hdl.handle.net/10316/11254
url https://hdl.handle.net/10316/11254
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Annual review of biophysics and biomolecular structure. 33 (2004) 269-295
1056-8700
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Annual Reviews
publisher.none.fl_str_mv Annual Reviews
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602343970537472

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