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Acute liver failure due to radiographically occult infiltration of urothelial cancer

Bibliographic Details
Main Author: Tosatto, Valentina
Publication Date: 2021
Other Authors: Pimentel, João Cabral, Cruz, Cristiano, Almeida, André, Boattini, Matteo
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/119309
Summary: Introduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.
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spelling Acute liver failure due to radiographically occult infiltration of urothelial cancerBiopsyNeoplasmsPalliative carePathology and Forensic MedicineInternal MedicineSDG 3 - Good Health and Well-beingIntroduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNTosatto, ValentinaPimentel, João CabralCruz, CristianoAlmeida, AndréBoattini, Matteo2021-06-15T22:20:56Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/119309eng2236-1960PURE: 29566868https://doi.org/10.4322/acr.2021.256info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:53:45Zoai:run.unl.pt:10362/119309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:24:55.000767Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Acute liver failure due to radiographically occult infiltration of urothelial cancer
title Acute liver failure due to radiographically occult infiltration of urothelial cancer
spellingShingle Acute liver failure due to radiographically occult infiltration of urothelial cancer
Tosatto, Valentina
Biopsy
Neoplasms
Palliative care
Pathology and Forensic Medicine
Internal Medicine
SDG 3 - Good Health and Well-being
title_short Acute liver failure due to radiographically occult infiltration of urothelial cancer
title_full Acute liver failure due to radiographically occult infiltration of urothelial cancer
title_fullStr Acute liver failure due to radiographically occult infiltration of urothelial cancer
title_full_unstemmed Acute liver failure due to radiographically occult infiltration of urothelial cancer
title_sort Acute liver failure due to radiographically occult infiltration of urothelial cancer
author Tosatto, Valentina
author_facet Tosatto, Valentina
Pimentel, João Cabral
Cruz, Cristiano
Almeida, André
Boattini, Matteo
author_role author
author2 Pimentel, João Cabral
Cruz, Cristiano
Almeida, André
Boattini, Matteo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Tosatto, Valentina
Pimentel, João Cabral
Cruz, Cristiano
Almeida, André
Boattini, Matteo
dc.subject.por.fl_str_mv Biopsy
Neoplasms
Palliative care
Pathology and Forensic Medicine
Internal Medicine
SDG 3 - Good Health and Well-being
topic Biopsy
Neoplasms
Palliative care
Pathology and Forensic Medicine
Internal Medicine
SDG 3 - Good Health and Well-being
description Introduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-15T22:20:56Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/119309
url http://hdl.handle.net/10362/119309
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2236-1960
PURE: 29566868
https://doi.org/10.4322/acr.2021.256
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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