The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates

Bibliographic Details
Main Author: Cunha, Pedro Silva
Publication Date: 2022
Other Authors: Laranjo, Sérgio, Heijman, Jordi, Oliveira, Mário Martins
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/148231
Summary: Funding Information: JH was supported by the “Netherlands Organization for Scientific Research NWO/ZonMWVidi 09150171910029”. PC, SL, and MO have not received any funding. Publisher Copyright: Copyright © 2022 Cunha, Laranjo, Heijman and Oliveira.
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spelling The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substratesatrial fibrillationatrial substratecatheter ablationfibrotic atrial myopathypathophysiologyCardiology and Cardiovascular MedicineFunding Information: JH was supported by the “Netherlands Organization for Scientific Research NWO/ZonMWVidi 09150171910029”. PC, SL, and MO have not received any funding. Publisher Copyright: Copyright © 2022 Cunha, Laranjo, Heijman and Oliveira.Atrial fibrillation (AF) is the most common sustained arrhythmia in the population and is associated with a significant clinical and economic burden. Rigorous assessment of the presence and degree of an atrial arrhythmic substrate is essential for determining treatment options, predicting long-term success after catheter ablation, and as a substrate critical in the pathophysiology of atrial thrombogenesis. Catheter ablation of AF has developed into an essential rhythm-control strategy. Nowadays is one of the most common cardiac ablation procedures performed worldwide, with its success inversely related to the extent of atrial structural disease. Although atrial substrate evaluation remains complex, several diagnostic resources allow for a more comprehensive assessment and quantification of the extent of left atrial structural remodeling and the presence of atrial fibrosis. In this review, we summarize the current knowledge on the pathophysiology, etiology, and electrophysiological aspects of atrial substrates promoting the development of AF. We also describe the risk factors for its development and how to diagnose its presence using imaging, electrocardiograms, and electroanatomic voltage mapping. Finally, we discuss recent data regarding fibrosis biomarkers that could help diagnose atrial fibrotic substrates.Comprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCunha, Pedro SilvaLaranjo, SérgioHeijman, JordiOliveira, Mário Martins2023-01-26T22:17:47Z2022-07-042022-07-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/148231eng2297-055XPURE: 51715346https://doi.org/10.3389/fcvm.2022.879984info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:08:35Zoai:run.unl.pt:10362/148231Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:57.272516Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
title The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
spellingShingle The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
Cunha, Pedro Silva
atrial fibrillation
atrial substrate
catheter ablation
fibrotic atrial myopathy
pathophysiology
Cardiology and Cardiovascular Medicine
title_short The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
title_full The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
title_fullStr The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
title_full_unstemmed The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
title_sort The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates
author Cunha, Pedro Silva
author_facet Cunha, Pedro Silva
Laranjo, Sérgio
Heijman, Jordi
Oliveira, Mário Martins
author_role author
author2 Laranjo, Sérgio
Heijman, Jordi
Oliveira, Mário Martins
author2_role author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - pólo NMS
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Cunha, Pedro Silva
Laranjo, Sérgio
Heijman, Jordi
Oliveira, Mário Martins
dc.subject.por.fl_str_mv atrial fibrillation
atrial substrate
catheter ablation
fibrotic atrial myopathy
pathophysiology
Cardiology and Cardiovascular Medicine
topic atrial fibrillation
atrial substrate
catheter ablation
fibrotic atrial myopathy
pathophysiology
Cardiology and Cardiovascular Medicine
description Funding Information: JH was supported by the “Netherlands Organization for Scientific Research NWO/ZonMWVidi 09150171910029”. PC, SL, and MO have not received any funding. Publisher Copyright: Copyright © 2022 Cunha, Laranjo, Heijman and Oliveira.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-04
2022-07-04T00:00:00Z
2023-01-26T22:17:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/148231
url http://hdl.handle.net/10362/148231
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2297-055X
PURE: 51715346
https://doi.org/10.3389/fcvm.2022.879984
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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