Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns

Bibliographic Details
Main Author: Grilo, Miguel
Publication Date: 2021
Other Authors: Isidoro, Sara, Chambel, Lélia, Marques, Carolina S., Marques, Tiago A., Sousa-Santos, C., Robalo, Joana, Oliveira, Manuela
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.5/22518
Summary: Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
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spelling Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patternsAeromonasAntimicrobial resistanceVirulenceTypingLeuciscidFishResearch Areas: Infectious Diseases ; Pharmacology & PharmacyDespite the fact that freshwater fish populations are experiencing severe declines worldwide, our knowledge on the interaction between endangered populations and pathogenic agents remains scarce. In this study, we investigated the prevalence and structure of Aeromonas communities isolated from the critically endangered Iberochondrostoma lusitanicum, a model species for threatened Iberian leuciscids, as well as health parameters in this species. Additionally, we evaluated the virulence profiles, antimicrobial resistance signatures and genomic relationships of the Aeromonas isolates. Lesion prevalence, extension and body condition were deeply affected by location and seasonality, with poorer performances in the dry season. Aeromonas composition shifted among seasons and was also different across river streams. The pathogenic potential of the isolates significantly increased during the dry season. Additionally, isolates displaying clinically relevant antimicrobial resistance phenotypes (carbapenem and fluroquinolone resistance) were detected. As it inhabits intermittent rivers, often reduced to disconnected pools during the summer, the dry season is a critical period for I. lusitanicum, with lower general health status and a higher potential of infection by Aeromonas spp. Habitat quality seems a determining factor on the sustainable development of this fish species. Also, these individuals act as reservoirs of important antimicrobial resistant bacteria with potential implications for public health.MDPIRepositório da Universidade de LisboaGrilo, MiguelIsidoro, SaraChambel, LéliaMarques, Carolina S.Marques, Tiago A.Sousa-Santos, C.Robalo, JoanaOliveira, Manuela2021-11-05T17:50:30Z2021-06-222021-06-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22518engGrilo ML, Isidoro S, Chambel L, Marques CS, Marques TA, Sousa-Santos C, Robalo JI, Oliveira M. 2021. Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns. Antibiotics, 10(7):759. DOI:10.3390/antibiotics100707592079-638210.3390/antibiotics10070759info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:24:22Zoai:repositorio.ulisboa.pt:10400.5/22518Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:42:25.122505Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
title Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
spellingShingle Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
Grilo, Miguel
Aeromonas
Antimicrobial resistance
Virulence
Typing
Leuciscid
Fish
title_short Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
title_full Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
title_fullStr Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
title_full_unstemmed Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
title_sort Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns
author Grilo, Miguel
author_facet Grilo, Miguel
Isidoro, Sara
Chambel, Lélia
Marques, Carolina S.
Marques, Tiago A.
Sousa-Santos, C.
Robalo, Joana
Oliveira, Manuela
author_role author
author2 Isidoro, Sara
Chambel, Lélia
Marques, Carolina S.
Marques, Tiago A.
Sousa-Santos, C.
Robalo, Joana
Oliveira, Manuela
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Grilo, Miguel
Isidoro, Sara
Chambel, Lélia
Marques, Carolina S.
Marques, Tiago A.
Sousa-Santos, C.
Robalo, Joana
Oliveira, Manuela
dc.subject.por.fl_str_mv Aeromonas
Antimicrobial resistance
Virulence
Typing
Leuciscid
Fish
topic Aeromonas
Antimicrobial resistance
Virulence
Typing
Leuciscid
Fish
description Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
publishDate 2021
dc.date.none.fl_str_mv 2021-11-05T17:50:30Z
2021-06-22
2021-06-22T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/22518
url http://hdl.handle.net/10400.5/22518
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Grilo ML, Isidoro S, Chambel L, Marques CS, Marques TA, Sousa-Santos C, Robalo JI, Oliveira M. 2021. Molecular epidemiology, virulence traits and antimicrobial resistance signatures of Aeromonas spp. in the critically endangered iberochondrostoma iusitanicum follow geographical and seasonal patterns. Antibiotics, 10(7):759. DOI:10.3390/antibiotics10070759
2079-6382
10.3390/antibiotics10070759
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601802632691712

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