Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento

Bibliographic Details
Main Author: Ramos, A.
Publication Date: 2012
Other Authors: Pereira, A., Cabrita, A. Silvério, Capela e Silva, F.
Format: Article
Language: por
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/109841
https://doi.org/10.1590/S0102-09352012000200035
Summary: The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism.
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spelling Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimentoEffects of semicarbazide on skeleton of growing Wistar ratsratWistarsemicarbazideosteolathyrismThe effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism.2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/109841https://hdl.handle.net/10316/109841https://doi.org/10.1590/S0102-09352012000200035por0102-0935Ramos, A.Pereira, A.Cabrita, A. SilvérioCapela e Silva, F.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2023-10-31T10:10:08Zoai:estudogeral.uc.pt:10316/109841Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:01:29.919058Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
Effects of semicarbazide on skeleton of growing Wistar rats
title Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
spellingShingle Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
Ramos, A.
rat
Wistar
semicarbazide
osteolathyrism
title_short Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
title_full Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
title_fullStr Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
title_full_unstemmed Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
title_sort Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
author Ramos, A.
author_facet Ramos, A.
Pereira, A.
Cabrita, A. Silvério
Capela e Silva, F.
author_role author
author2 Pereira, A.
Cabrita, A. Silvério
Capela e Silva, F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ramos, A.
Pereira, A.
Cabrita, A. Silvério
Capela e Silva, F.
dc.subject.por.fl_str_mv rat
Wistar
semicarbazide
osteolathyrism
topic rat
Wistar
semicarbazide
osteolathyrism
description The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/109841
https://hdl.handle.net/10316/109841
https://doi.org/10.1590/S0102-09352012000200035
url https://hdl.handle.net/10316/109841
https://doi.org/10.1590/S0102-09352012000200035
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 0102-0935
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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