In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds

• Main Author: DA SILVA, Beatriz R.M.G.
• Publication Date: 2023
• Other Authors: DA SILVA BEZERRA JÚNIOR, Natanael, DE OLIVEIRA, Jamerson F., Duarte, Denise Maria F. A., Marques, Diego S.C., Nogueira, Fátima, DE LIMA, Maria Carmo A., DA CRUZ FILHO, Iranildo José
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10362/164554
• topic: ADMET; antimalarial activity; mammalian cell cytotoxicity; thiazoles; RM Therapeutics. Pharmacology; QR Microbiology; Infectious Diseases; Parasitology; Drug Discovery; Pharmacology, Toxicology and Pharmaceutics(all); SDG 3 - Good Health and Well-being; SDG 9 - Industry, Innovation, and Infrastructure

Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco-FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant-FACEPE (Process BFP-0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco - FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant -FACEPE (Process BFP -0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, Academia Brasileira de Ciencias. All rights reserved.