The role of ionic liquids in the pharmaceutical field: an overview of relevant applications

Bibliographic Details
Main Author: Pedro, Sónia N.
Publication Date: 2020
Other Authors: Freire, Carmen S. R., Silvestre, Armando J. D., Freire, Mara G.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10773/30886
Summary: Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.
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spelling The role of ionic liquids in the pharmaceutical field: an overview of relevant applicationsActive pharmaceutical ingredientsDrug delivery systemsFormulationsIonic liquidsSolubilityPermeabilitySolubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.MDPI2021-03-16T11:15:36Z2020-11-05T00:00:00Z2020-11-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/30886eng1661-659610.3390/ijms21218298Pedro, Sónia N.Freire, Carmen S. R.Silvestre, Armando J. D.Freire, Mara G.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-06T04:30:51Zoai:ria.ua.pt:10773/30886Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:11:11.752347Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
title The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
spellingShingle The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
Pedro, Sónia N.
Active pharmaceutical ingredients
Drug delivery systems
Formulations
Ionic liquids
Solubility
Permeability
title_short The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
title_full The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
title_fullStr The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
title_full_unstemmed The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
title_sort The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
author Pedro, Sónia N.
author_facet Pedro, Sónia N.
Freire, Carmen S. R.
Silvestre, Armando J. D.
Freire, Mara G.
author_role author
author2 Freire, Carmen S. R.
Silvestre, Armando J. D.
Freire, Mara G.
author2_role author
author
author
dc.contributor.author.fl_str_mv Pedro, Sónia N.
Freire, Carmen S. R.
Silvestre, Armando J. D.
Freire, Mara G.
dc.subject.por.fl_str_mv Active pharmaceutical ingredients
Drug delivery systems
Formulations
Ionic liquids
Solubility
Permeability
topic Active pharmaceutical ingredients
Drug delivery systems
Formulations
Ionic liquids
Solubility
Permeability
description Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-05T00:00:00Z
2020-11-05
2021-03-16T11:15:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/30886
url http://hdl.handle.net/10773/30886
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
10.3390/ijms21218298
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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