Hypersensitivity pneumonitis: antigen diversity and disease implications

Bibliographic Details
Main Author: Nogueira, R.
Publication Date: 2019
Other Authors: Melo, N., Bastos, Hélder Novais, Martins, N., Delgado, L., Morais, A., Mota, P. C.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/58100
Summary: Article in Press
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spelling Hypersensitivity pneumonitis: antigen diversity and disease implicationsAntigenDiagnosisHypersensitivity pneumonitisPrognosisResearch methodsScience & TechnologyArticle in PressHypersensitivity pneumonitis (HP) is an immune-mediated syndrome triggered by inhalation of a wide variety of allergens, to which an individual has previously been sensitized. More than 200 agents responsible for the disease have already been identified; however, HP occurs only in a small number of individuals exposed to causal antigens. The present report provides an overview of the role of antigen role in HP, highlighting its diversity, research methods, and prevention strategies, as well as the impact on disease prognosis following elimination of antigen. HP is an underdiagnosed disease and, therefore, it is difficult to accurately estimate its incidence. Triggering antigens can be divided into six broad categories: bacteria, fungi, mycobacteria, animal and plant proteins, chemicals, and metals, represented by disease prototypes. The identification of causal antigen is a major challenge; it is impossible to obtain in about 30-60% of cases. The acute form of HP, with early detection and immediate eviction of causal antigen, tends to have an excellent prognosis. In the chronic form, partial recovery of disease is still possible; however, some cases tend to progress to fibrosis, even after removal from exposure. In conclusion, HP diagnosis should be based on a proactive search for potential antigen sources, although their identification is hampered by the lack of standardized methods of demonstrating the specific antigen sensitization. Antigen avoidance is a critical determinant in disease prognosis.(undefined)info:eu-repo/semantics/acceptedVersionElsevier EspañaUniversidade do MinhoNogueira, R.Melo, N.Bastos, Hélder NovaisMartins, N.Delgado, L.Morais, A.Mota, P. C.20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58100eng2531-042910.1016/j.pulmoe.2018.07.00330126802info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:38:45Zoai:repositorium.sdum.uminho.pt:1822/58100Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:59:44.698699Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Hypersensitivity pneumonitis: antigen diversity and disease implications
title Hypersensitivity pneumonitis: antigen diversity and disease implications
spellingShingle Hypersensitivity pneumonitis: antigen diversity and disease implications
Nogueira, R.
Antigen
Diagnosis
Hypersensitivity pneumonitis
Prognosis
Research methods
Science & Technology
title_short Hypersensitivity pneumonitis: antigen diversity and disease implications
title_full Hypersensitivity pneumonitis: antigen diversity and disease implications
title_fullStr Hypersensitivity pneumonitis: antigen diversity and disease implications
title_full_unstemmed Hypersensitivity pneumonitis: antigen diversity and disease implications
title_sort Hypersensitivity pneumonitis: antigen diversity and disease implications
author Nogueira, R.
author_facet Nogueira, R.
Melo, N.
Bastos, Hélder Novais
Martins, N.
Delgado, L.
Morais, A.
Mota, P. C.
author_role author
author2 Melo, N.
Bastos, Hélder Novais
Martins, N.
Delgado, L.
Morais, A.
Mota, P. C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Nogueira, R.
Melo, N.
Bastos, Hélder Novais
Martins, N.
Delgado, L.
Morais, A.
Mota, P. C.
dc.subject.por.fl_str_mv Antigen
Diagnosis
Hypersensitivity pneumonitis
Prognosis
Research methods
Science & Technology
topic Antigen
Diagnosis
Hypersensitivity pneumonitis
Prognosis
Research methods
Science & Technology
description Article in Press
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58100
url http://hdl.handle.net/1822/58100
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2531-0429
10.1016/j.pulmoe.2018.07.003
30126802
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier España
publisher.none.fl_str_mv Elsevier España
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595671688511488

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