Evaluating evolutionary multiobjective algorithms for the in silico optimization of mutant strains

• Main Author: Maia, Paulo
• Publication Date: 2008
• Other Authors: Rocha, I., Ferreira, Eugénio C., Rocha, Miguel
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/1822/16649
• topic: Multiobjective evolutionary algorithms; Metabolic engineering; Flux-balance analysis; Systems biology; Science & Technology

In Metabolic Engineering, the identification of genetic manipulations that lead to mutant strains able to produce a given compound of interest is a promising, while still complex process. Evolutionary Algorithms (EAs) have been a successful approach for tackling the underlying in silico optimization problems. The most common task is to solve a bi-level optimization problem, where the strain that maximizes the production of some compound is sought, while trying to keep the organism viable (maximizing biomass). In this work, this task is viewed as a multiobjective optimization problem and an approach based on multiobjective EAs is proposed. The algorithms are validated with a real world case study that uses E. coli to produce succinic acid. The results obtained are quite promising when compared to the available single objective algorithms.