Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases
| Main Author: | |
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| Publication Date: | 2019 |
| Other Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10451/49209 |
Summary: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastasesFGF23Bone metastasesCancerPrognosis© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).The fibroblast growth factor (FGF) signaling pathway plays a key role in tumorigenesis and is recognized as a potential therapeutic target. In this study, the authors aimed to assess the impact of serum FGF23 levels in the prognosis of patients with cancer and bone metastases from solid tumors. A cohort of 112 patients with cancer and metastatic bone disease were treated with bone-targeted agents (BTA). Serum baseline FGF23 was quantified by ELISA and dichotomized in FGF23high and FGF23low groups. Additionally, the association between FGF23 and overall survival (OS) and time to skeletal-related events (TTSRE) was investigated. Baseline characteristics were balanced between groups, except for the median urinary N-terminal telopeptide (uNTX) level. After a median follow-up of 26.0 months, a median OS of 34.4 and 12.2 months was found in the FGF23low and FGF23high groups, respectively (multivariate HR 0.18, 95% CI 0.07⁻0.44, p = 0.001; univariate HR 0.27, p = 0.001). Additionally, TTSRE was significantly longer for patients with FGF23low (13.0 vs 2.0 months, p = 0.04). Overall, this study found that patients with FGF23low at baseline had longer OS and TTSRE. Further studies are warranted to define its role as a prognostic biomarker and in the use of drugs targeting the FGF axis.This research received funding from an anonymous non-pharma related individual in the form of donation. This study was supported by project UID/BIM/50005/2019 of Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through State Budget funding.MDPIRepositório da Universidade de LisboaMansinho, AndréFerreira, ArlindoCasimiro, SandraAlho, IrinaVendrell, InesCosta, Ana LúciaSousa, RitaMarques, CatarinaPulido, CatarinaMacedo, DanielaPacheco, TeresaCorreia, LurdesCosta, Luis2021-07-29T13:36:02Z2019-02-062019-02-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49209engMansinho A, Ferreira AR, Casimiro S, Alho I, Vendrell I, Costa AL, Sousa R, Abreu C, Pulido C, Macedo D, Pacheco TR, Correia L, Costa L. Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases. Int J Mol Sci. 2019 Feb 6;20(3):6951661-659610.3390/ijms200306951422-0067info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:36:09Zoai:repositorio.ulisboa.pt:10451/49209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:16:45.759557Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| title |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| spellingShingle |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases Mansinho, André FGF23 Bone metastases Cancer Prognosis |
| title_short |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| title_full |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| title_fullStr |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| title_full_unstemmed |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| title_sort |
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases |
| author |
Mansinho, André |
| author_facet |
Mansinho, André Ferreira, Arlindo Casimiro, Sandra Alho, Irina Vendrell, Ines Costa, Ana Lúcia Sousa, Rita Marques, Catarina Pulido, Catarina Macedo, Daniela Pacheco, Teresa Correia, Lurdes Costa, Luis |
| author_role |
author |
| author2 |
Ferreira, Arlindo Casimiro, Sandra Alho, Irina Vendrell, Ines Costa, Ana Lúcia Sousa, Rita Marques, Catarina Pulido, Catarina Macedo, Daniela Pacheco, Teresa Correia, Lurdes Costa, Luis |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Mansinho, André Ferreira, Arlindo Casimiro, Sandra Alho, Irina Vendrell, Ines Costa, Ana Lúcia Sousa, Rita Marques, Catarina Pulido, Catarina Macedo, Daniela Pacheco, Teresa Correia, Lurdes Costa, Luis |
| dc.subject.por.fl_str_mv |
FGF23 Bone metastases Cancer Prognosis |
| topic |
FGF23 Bone metastases Cancer Prognosis |
| description |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-02-06 2019-02-06T00:00:00Z 2021-07-29T13:36:02Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/49209 |
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http://hdl.handle.net/10451/49209 |
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eng |
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eng |
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Mansinho A, Ferreira AR, Casimiro S, Alho I, Vendrell I, Costa AL, Sousa R, Abreu C, Pulido C, Macedo D, Pacheco TR, Correia L, Costa L. Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases. Int J Mol Sci. 2019 Feb 6;20(3):695 1661-6596 10.3390/ijms20030695 1422-0067 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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