ASSERT trial - How to assess the safety and efficacy of a high frequency rTMS in postpartum depression ? A multicenter, double blinded, randomized, placebo-controlled clinical trial

• Main Author: Andriotti, Tomas
• Publication Date: 2017
• Other Authors: Stavale, Rafaelly, Nafee, Tarek, Fakhry, Stephanie, Mohamed, Mahmoud M. A., Sofiyeva, Nigar, Ganho-Ávila, Ana, Bogner, Andreas, Barbosa, Sara P., Piton, Luciana S., Hirayama, André Luís S., Gaccia, Gisele, Smith-Howard Junior, Tomas P., Miranda, Priscila C., Reyes, Karen J. Campoverde, Gragera, Alvaro, Nishiwaki, Hiroki, Boechat-Barros, Raphael
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/10316/108131; https://doi.org/10.1016/j.conctc.2017.01.004
• topic: Postpartum depression;; repetitive Transcranial Magnetic; Stimulation; Research clinical trial

Background: Postpartum Depression affects a considerable number of women worldwide. This condition inflicts severe consequences to mother and child health. Thus far, available treatments have low response and high relapse rates. We designed this trial to evaluate a safe and more efficacious innovative therapy. Aims: To report a feasible and ethical study design to assess the safety and efficacy of a high frequency repetitive Transcranial Magnetic Stimulation 10 Hz (rTMS) compared to sham rTMS in women with moderate to severe Post-Partum Depression using standard treatment (sertraline).