Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

Bibliographic Details
Main Author: Fernandes, Samuel
Publication Date: 2022
Other Authors: Serrazina, Juliana, Botto, Inês Ayala, Leal, Tiago, Guimarães, Andreia, Garcia, Joana Lemos, Rosa, Isadora, Prata, Rita, Carvalho, Diana, Neves, João, Campelo, Pedro, Ventura, Sofia, Silva, Andrea, Coelho, Mariana, Sequeira, Cristiana, Oliveira, Ana Paula, Portela, Francisco, Ministro, Paula, Tavares de Sousa, Helena, Ramos, Jaime, Claro, Isabel, Gonçalves, Raquel, Correia, Luís Araújo, Marinho, Rui, Cortez-Pinto, Helena, Magro, Fernando
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/56240
Summary: © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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spelling Transmural remission improves clinical outcomes up to 5 years in Crohn's diseaseCrohn's diseaseMRI enterographyEndoscopyInflammatory bowel diseaseTransmural remission© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.Introduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five-year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between patients with TR, IER, IRR, and no remission (NR). Results: 20.8% of CD patients presented TR, 23.3% IER, 13.6% IRR and 42.3% NR. TR was associated with lower risk of hospitalization (odds-ratio [OR] 0.244 [0.111-0.538], p < 0.001), surgery (OR 0.132 [0.030-0.585], p = 0.008), steroid use (OR 0.283 [0.159-0.505], p < 0.001), and treatment escalation (OR 0.088 [0.044-0.176], p < 0.001) compared to no NR. IRR resulted in lower risk of hospitalization (OR 0.333 [0.143-0.777], p = 0.011) and treatment escalation (OR 0.260 [0.125-0.540], p < 0.001), while IER reduced the risk of steroid use (OR 0.442 [0.262-0.745], p = 0.002) and treatment escalation (OR 0.490 [0.259-0.925], p = 0.028) compared to NR. Conclusions: TR improved clinical outcomes over 5 years of follow-up in CD patients. Distinct but significant benefits were seen with IER and IRR. This suggests that both endoscopic and radiologic remission should be part of the treatment targets of CD.WileyRepositório da Universidade de LisboaFernandes, SamuelSerrazina, JulianaBotto, Inês AyalaLeal, TiagoGuimarães, AndreiaGarcia, Joana LemosRosa, IsadoraPrata, RitaCarvalho, DianaNeves, JoãoCampelo, PedroVentura, SofiaSilva, AndreaCoelho, MarianaSequeira, CristianaOliveira, Ana PaulaPortela, FranciscoMinistro, PaulaTavares de Sousa, HelenaRamos, JaimeClaro, IsabelGonçalves, RaquelCorreia, Luís AraújoMarinho, RuiCortez-Pinto, HelenaMagro, Fernando2023-02-09T12:39:41Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56240engUnited European Gastroenterol J. 2023 Feb;11(1):51-592050-640610.1002/ueg2.123562050-6414info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:53:45Zoai:repositorio.ulisboa.pt:10451/56240Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:28:04.327554Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
title Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
spellingShingle Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
Fernandes, Samuel
Crohn's disease
MRI enterography
Endoscopy
Inflammatory bowel disease
Transmural remission
title_short Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
title_full Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
title_fullStr Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
title_full_unstemmed Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
title_sort Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
author Fernandes, Samuel
author_facet Fernandes, Samuel
Serrazina, Juliana
Botto, Inês Ayala
Leal, Tiago
Guimarães, Andreia
Garcia, Joana Lemos
Rosa, Isadora
Prata, Rita
Carvalho, Diana
Neves, João
Campelo, Pedro
Ventura, Sofia
Silva, Andrea
Coelho, Mariana
Sequeira, Cristiana
Oliveira, Ana Paula
Portela, Francisco
Ministro, Paula
Tavares de Sousa, Helena
Ramos, Jaime
Claro, Isabel
Gonçalves, Raquel
Correia, Luís Araújo
Marinho, Rui
Cortez-Pinto, Helena
Magro, Fernando
author_role author
author2 Serrazina, Juliana
Botto, Inês Ayala
Leal, Tiago
Guimarães, Andreia
Garcia, Joana Lemos
Rosa, Isadora
Prata, Rita
Carvalho, Diana
Neves, João
Campelo, Pedro
Ventura, Sofia
Silva, Andrea
Coelho, Mariana
Sequeira, Cristiana
Oliveira, Ana Paula
Portela, Francisco
Ministro, Paula
Tavares de Sousa, Helena
Ramos, Jaime
Claro, Isabel
Gonçalves, Raquel
Correia, Luís Araújo
Marinho, Rui
Cortez-Pinto, Helena
Magro, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fernandes, Samuel
Serrazina, Juliana
Botto, Inês Ayala
Leal, Tiago
Guimarães, Andreia
Garcia, Joana Lemos
Rosa, Isadora
Prata, Rita
Carvalho, Diana
Neves, João
Campelo, Pedro
Ventura, Sofia
Silva, Andrea
Coelho, Mariana
Sequeira, Cristiana
Oliveira, Ana Paula
Portela, Francisco
Ministro, Paula
Tavares de Sousa, Helena
Ramos, Jaime
Claro, Isabel
Gonçalves, Raquel
Correia, Luís Araújo
Marinho, Rui
Cortez-Pinto, Helena
Magro, Fernando
dc.subject.por.fl_str_mv Crohn's disease
MRI enterography
Endoscopy
Inflammatory bowel disease
Transmural remission
topic Crohn's disease
MRI enterography
Endoscopy
Inflammatory bowel disease
Transmural remission
description © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-02-09T12:39:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56240
url http://hdl.handle.net/10451/56240
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv United European Gastroenterol J. 2023 Feb;11(1):51-59
2050-6406
10.1002/ueg2.12356
2050-6414
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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