Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10362/132538 |
Resumo: | ..870-15 SC; the United States Agency for International Development (USAID), grant number AID-656-F-16-00002 and Fundo Nacional de Investiga??o (FNI), Mo?ambique, grant number 245-INV, within the context of diarrhoeal disease surveillance platform implementation. F.M PhD is supported by Calouste Gulbenkian Foundation, grant number 234066. The authors convey many thanks to all the caregivers who consented to their children?s participation in both studies (GEMS and the diarrhoeal disease platform). They would also like to thank all the professionals in the hospitals and those on field recruitment for their full dedication and effort in children enrolment and collection of data and samples whenever possible. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
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Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019Case-control studyGenotypesMozambiqueRotavirus AInfectious DiseasesVirologySDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesSDG 6 - Clean Water and SanitationSDG 14 - Life Below Water..870-15 SC; the United States Agency for International Development (USAID), grant number AID-656-F-16-00002 and Fundo Nacional de Investiga??o (FNI), Mo?ambique, grant number 245-INV, within the context of diarrhoeal disease surveillance platform implementation. F.M PhD is supported by Calouste Gulbenkian Foundation, grant number 234066. The authors convey many thanks to all the caregivers who consented to their children?s participation in both studies (GEMS and the diarrhoeal disease platform). They would also like to thank all the professionals in the hospitals and those on field recruitment for their full dedication and effort in children enrolment and collection of data and samples whenever possible. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix® ) in September 2015. We report rotavirus geno-types circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre-and post-vaccine introduction. Stool was collected from enrolled children and screened for ro-tavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, p < 0.0001) and controls (23%, 26/113 vs. 0, p = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, p = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, p = 0.0002; and 14%, 7/49 vs. 1%, 1/177, p < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, p = 0.003; and 24%, 14/58 vs. 0, p < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre-to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)RUNManjate, FilomenaJoão, Eva D.Chirinda, PercinaGarrine, MarcelinoVubil, DelfinoNobela, NélioKotloff, KarenNataro, James P.Nhampossa, TaciltaAcácio, SozinhoTate, Jacqueline E.Parashar, UmeshMwenda, Jason M.Alonso, Pedro L.Nyaga, MartinCunha, CelsoMandomando, Inácio2022-02-08T23:22:56Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/132538eng1999-4915PURE: 36376352https://doi.org/10.3390/v14010134info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:59:14Zoai:run.unl.pt:10362/132538Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:30:20.559690Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| title |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| spellingShingle |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 Manjate, Filomena Case-control study Genotypes Mozambique Rotavirus A Infectious Diseases Virology SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities SDG 6 - Clean Water and Sanitation SDG 14 - Life Below Water |
| title_short |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| title_full |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| title_fullStr |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| title_full_unstemmed |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| title_sort |
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
| author |
Manjate, Filomena |
| author_facet |
Manjate, Filomena João, Eva D. Chirinda, Percina Garrine, Marcelino Vubil, Delfino Nobela, Nélio Kotloff, Karen Nataro, James P. Nhampossa, Tacilta Acácio, Sozinho Tate, Jacqueline E. Parashar, Umesh Mwenda, Jason M. Alonso, Pedro L. Nyaga, Martin Cunha, Celso Mandomando, Inácio |
| author_role |
author |
| author2 |
João, Eva D. Chirinda, Percina Garrine, Marcelino Vubil, Delfino Nobela, Nélio Kotloff, Karen Nataro, James P. Nhampossa, Tacilta Acácio, Sozinho Tate, Jacqueline E. Parashar, Umesh Mwenda, Jason M. Alonso, Pedro L. Nyaga, Martin Cunha, Celso Mandomando, Inácio |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) TB, HIV and opportunistic diseases and pathogens (THOP) RUN |
| dc.contributor.author.fl_str_mv |
Manjate, Filomena João, Eva D. Chirinda, Percina Garrine, Marcelino Vubil, Delfino Nobela, Nélio Kotloff, Karen Nataro, James P. Nhampossa, Tacilta Acácio, Sozinho Tate, Jacqueline E. Parashar, Umesh Mwenda, Jason M. Alonso, Pedro L. Nyaga, Martin Cunha, Celso Mandomando, Inácio |
| dc.subject.por.fl_str_mv |
Case-control study Genotypes Mozambique Rotavirus A Infectious Diseases Virology SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities SDG 6 - Clean Water and Sanitation SDG 14 - Life Below Water |
| topic |
Case-control study Genotypes Mozambique Rotavirus A Infectious Diseases Virology SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities SDG 6 - Clean Water and Sanitation SDG 14 - Life Below Water |
| description |
..870-15 SC; the United States Agency for International Development (USAID), grant number AID-656-F-16-00002 and Fundo Nacional de Investiga??o (FNI), Mo?ambique, grant number 245-INV, within the context of diarrhoeal disease surveillance platform implementation. F.M PhD is supported by Calouste Gulbenkian Foundation, grant number 234066. The authors convey many thanks to all the caregivers who consented to their children?s participation in both studies (GEMS and the diarrhoeal disease platform). They would also like to thank all the professionals in the hospitals and those on field recruitment for their full dedication and effort in children enrolment and collection of data and samples whenever possible. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-02-08T23:22:56Z 2022-01 2022-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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eng |
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1999-4915 PURE: 36376352 https://doi.org/10.3390/v14010134 |
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