Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications

Bibliographic Details
Main Author: Carrelo, Henrique
Publication Date: 2023
Other Authors: Escoval, André R., Vieira, Tânia, Jiménez-Rosado, Mercedes, Silva, Jorge Carvalho, Romero, Alberto, Soares, Paula Isabel P., Borges, João Paulo
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/162710
Summary: This work is funded by National Funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. This study was also financially supported by MCIN/AEI/10.13039/501100011033///FEDER, UE, through project PID2021-124294OB-C21. Publisher Copyright: © 2023 by the authors.
id RCAP_e93f56b289e6eeadb7b5f31ffcf2a859
oai_identifier_str oai:run.unl.pt:10362/162710
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia ApplicationshydrogelsmicroparticlesPluronicrheologyBioengineeringBiomaterialsOrganic ChemistryPolymers and PlasticsSDG 3 - Good Health and Well-beingThis work is funded by National Funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. This study was also financially supported by MCIN/AEI/10.13039/501100011033///FEDER, UE, through project PID2021-124294OB-C21. Publisher Copyright: © 2023 by the authors.Cancer is a disease that continues to greatly impact our society. Developing new and more personalized treatment options is crucial to decreasing the cancer burden. In this study, we combined magnetic polysaccharide microparticles with a Pluronic thermoresponsive hydrogel to develop a multifunctional, injectable drug delivery system (DDS) for magnetic hyperthermia applications. Gellan gum and alginate microparticles were loaded with superparamagnetic iron oxide nanoparticles (SPIONs) with and without coating. The magnetic microparticles’ registered temperature increases up to 4 °C upon the application of an alternating magnetic field. These magnetic microparticles were mixed with drug-loaded microparticles, and, subsequently, this mixture was embedded within a Pluronic thermoresponsive hydrogel that is capable of being in the gel state at 37 °C. The proposed DDS was capable of slowly releasing methylene blue, used as a model drug, for up to 9 days. The developed hydrogel/microparticle system had a smaller rate of drug release compared with microparticles alone. This system proved to be a potential thermoresponsive DDS suitable for magnetic hyperthermia applications, thus enabling a synergistic treatment for cancer.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaRUNCarrelo, HenriqueEscoval, André R.Vieira, TâniaJiménez-Rosado, MercedesSilva, Jorge CarvalhoRomero, AlbertoSoares, Paula Isabel P.Borges, João Paulo2024-01-24T17:02:12Z2023-12-152023-12-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/162710eng2310-2861PURE: 81996763https://doi.org/10.3390/gels9120982info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:17:42Zoai:run.unl.pt:10362/162710Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:48:11.441828Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
spellingShingle Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
Carrelo, Henrique
hydrogels
microparticles
Pluronic
rheology
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
title_short Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_full Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_fullStr Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_full_unstemmed Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_sort Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
author Carrelo, Henrique
author_facet Carrelo, Henrique
Escoval, André R.
Vieira, Tânia
Jiménez-Rosado, Mercedes
Silva, Jorge Carvalho
Romero, Alberto
Soares, Paula Isabel P.
Borges, João Paulo
author_role author
author2 Escoval, André R.
Vieira, Tânia
Jiménez-Rosado, Mercedes
Silva, Jorge Carvalho
Romero, Alberto
Soares, Paula Isabel P.
Borges, João Paulo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Carrelo, Henrique
Escoval, André R.
Vieira, Tânia
Jiménez-Rosado, Mercedes
Silva, Jorge Carvalho
Romero, Alberto
Soares, Paula Isabel P.
Borges, João Paulo
dc.subject.por.fl_str_mv hydrogels
microparticles
Pluronic
rheology
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
topic hydrogels
microparticles
Pluronic
rheology
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
description This work is funded by National Funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. This study was also financially supported by MCIN/AEI/10.13039/501100011033///FEDER, UE, through project PID2021-124294OB-C21. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-15
2023-12-15T00:00:00Z
2024-01-24T17:02:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/162710
url http://hdl.handle.net/10362/162710
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2310-2861
PURE: 81996763
https://doi.org/10.3390/gels9120982
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596975571795968

Similar Items