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YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Bibliographic Details
Main Author: Neto, Filipa
Publication Date: 2018
Other Authors: Klaus-Bergmann, Alexandra, Ong, Yu Ting, Alt, Silvanus, Vion, Anne-Clémence, Szymborska, Anna, Carvalho, Joana R., Hollfinger, Irene, Bartels-Klein, Eireen, Franco, Claudio, Potente, Michael, Gerhardt, Holger
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/50248
Summary: © Copyright Neto et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
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spelling YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular developmentBMPTAZVE-CadherinYAPCell biologyDevelopmental biologyMouseStem cellsVascular development© Copyright Neto et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers and arrange suitably to shape functional vascular networks is poorly understood. Here we show that YAP/TAZ promote stretch-induced proliferation and rearrangements of endothelial cells whilst preventing bleeding in developing vessels. Mechanistically, YAP/TAZ increase the turnover of VE-Cadherin and the formation of junction associated intermediate lamellipodia, promoting both cell migration and barrier function maintenance. This is achieved in part by lowering BMP signalling. Consequently, the loss of YAP/TAZ in the mouse leads to stunted sprouting with local aggregation as well as scarcity of endothelial cells, branching irregularities and junction defects. Forced nuclear activity of TAZ instead drives hypersprouting and vascular hyperplasia. We propose a new model in which YAP/TAZ integrate mechanical signals with BMP signaling to maintain junctional compliance and integrity whilst balancing endothelial cell rearrangements in angiogenic vessels.FN was financially supported by the Fundação para a Ciência e a Tecnologia (FCT), CRUK-CRICK and the MDC. ACV, AKB and EBK were supported by the DZHK (German Centre for Cardiovascular Research), AS was supported by the EMBO (European Molecular Biology Organization), JRC was supported by the FCT. CAF is supported by the FCT, EC-ERC Starting Grant, Portugal2020 program. MP is supported by the Max Planck Society, the ERC Starting Grant ANGIOMET, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Cardiopulmonary System, the LOEWE grant Ub-Net, the DZHK, the Stiftung Charité and the EMBO Young Investigator Program. HG is supported by the DZHK and ERC Consolidator Grant Reshape 311719.eLife Sciences Publications Ltd.Repositório da Universidade de LisboaNeto, FilipaKlaus-Bergmann, AlexandraOng, Yu TingAlt, SilvanusVion, Anne-ClémenceSzymborska, AnnaCarvalho, Joana R.Hollfinger, IreneBartels-Klein, EireenFranco, ClaudioPotente, MichaelGerhardt, Holger2021-12-02T15:17:40Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50248engElife. 2018 Feb 5;7:e3103710.7554/eLife.310372050-084Xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:38:29Zoai:repositorio.ulisboa.pt:10451/50248Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:18:58.624735Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
title YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
spellingShingle YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
Neto, Filipa
BMP
TAZ
VE-Cadherin
YAP
Cell biology
Developmental biology
Mouse
Stem cells
Vascular development
title_short YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
title_full YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
title_fullStr YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
title_full_unstemmed YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
title_sort YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
author Neto, Filipa
author_facet Neto, Filipa
Klaus-Bergmann, Alexandra
Ong, Yu Ting
Alt, Silvanus
Vion, Anne-Clémence
Szymborska, Anna
Carvalho, Joana R.
Hollfinger, Irene
Bartels-Klein, Eireen
Franco, Claudio
Potente, Michael
Gerhardt, Holger
author_role author
author2 Klaus-Bergmann, Alexandra
Ong, Yu Ting
Alt, Silvanus
Vion, Anne-Clémence
Szymborska, Anna
Carvalho, Joana R.
Hollfinger, Irene
Bartels-Klein, Eireen
Franco, Claudio
Potente, Michael
Gerhardt, Holger
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Neto, Filipa
Klaus-Bergmann, Alexandra
Ong, Yu Ting
Alt, Silvanus
Vion, Anne-Clémence
Szymborska, Anna
Carvalho, Joana R.
Hollfinger, Irene
Bartels-Klein, Eireen
Franco, Claudio
Potente, Michael
Gerhardt, Holger
dc.subject.por.fl_str_mv BMP
TAZ
VE-Cadherin
YAP
Cell biology
Developmental biology
Mouse
Stem cells
Vascular development
topic BMP
TAZ
VE-Cadherin
YAP
Cell biology
Developmental biology
Mouse
Stem cells
Vascular development
description © Copyright Neto et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-12-02T15:17:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50248
url http://hdl.handle.net/10451/50248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Elife. 2018 Feb 5;7:e31037
10.7554/eLife.31037
2050-084X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications Ltd.
publisher.none.fl_str_mv eLife Sciences Publications Ltd.
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601660597829632

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