Multimorbidity is associated with fragility fractures in women 50 years and older

Bibliographic Details
Main Author: Barcelos, Anabela
Publication Date: 2021
Other Authors: Lopes, David G., Canhão, Helena, Branco, Jaime, Maria Rodrigues, Ana
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/133487
Summary: Funding Information: The study was supported by unrestricted grants from Direcção-Geral da Saúde , Fundação Calouste Gulbenkian , Fundação Champalimaud , Fundação AstraZeneca , Abbvie , Merck, Sharp & Dohme , Pfizer , Roche , Servier , Bial , D3A Medical Systems , Happybrands , Center de Medicina Laboratorial Germano de Sousa , Clínica Médica da Praia da Vitória , CAL-Clínica , Galp Energia , Açoreana Seguros , and individual rheumatologists .
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spelling Multimorbidity is associated with fragility fractures in women 50 years and olderA nationwide cross-sectional studyFragility fracturesMultimorbidityOsteoporosisWomenEndocrinology, Diabetes and MetabolismOrthopedics and Sports MedicineSDG 3 - Good Health and Well-beingFunding Information: The study was supported by unrestricted grants from Direcção-Geral da Saúde , Fundação Calouste Gulbenkian , Fundação Champalimaud , Fundação AstraZeneca , Abbvie , Merck, Sharp & Dohme , Pfizer , Roche , Servier , Bial , D3A Medical Systems , Happybrands , Center de Medicina Laboratorial Germano de Sousa , Clínica Médica da Praia da Vitória , CAL-Clínica , Galp Energia , Açoreana Seguros , and individual rheumatologists .Introduction: Multimorbidity is a worldwide health problem, especially in elderly patients who have a higher risk of fragility fracture. Currently, there is insufficient knowledge about the burden of multimorbidity in patients with previous fragility fracture. The aim of this study was to evaluate the association between multimorbidity and previous fragility fracture, and to assess the effect of fragility fracture and/or multimorbidity in the perception of quality-of-life and physical function, in women 50 years of age and older. Methods: Women aged ≥50 years from the EpiReumaPt study (2011−2013), a nationwide population-based study, were evaluated. Self-reported data regarding sociodemographics, health-related quality of life, physical functioning, fragility fracture, and multimorbidity were collected using a semi-structured questionnaire. Multimorbidity was defined as 2 or more chronic non-communicable diseases. Descriptive exploratory analysis of the data was performed using hypothesis testing. Multiple logistic regression modelling was used to assess the association between multimorbidity and fragility fractures, and linear regression was used for the quality-of-life and physical function outcomes. Results: The estimated prevalence of fragility fracture in women older than 50 years was 17.5%. A higher prevalence of multimorbidity (74.6%) was found in the group of women with previous fragility fracture than in those without previous fragility fracture. Multivariate logistic regression analysis revealed that women with multimorbidity had a higher odds of fragility fracture (adjusted odds ratio, 1.38; 95% confidence interval, 1.12–1.69), compared with women with 1 or no self-reported non-communicable chronic diseases. In women with previous fragility fracture, rheumatic diseases (62.7%) and hypertension (58.6%) were the most frequently self-reported non-communicable chronic diseases. Both multimorbidity and a previous fragility fracture were independently associated with worse health-related quality of life and physical functioning. Conclusions: Women 50 years and older with multimorbidity had a significantly increased odds of fragility fracture. Fragility fracture and multimorbidity were negatively associated with quality of life and disability. This study emphasizes the need to redesign health services to care for patients to prevent non-communicable chronic diseases and fragility fracture, particularly in women 50 years and older, in whom these diseases are likely to potentiate the risk of fragility fracture.Escola Nacional de Saúde Pública (ENSP)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Estudos de Doenças Crónicas (CEDOC)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNBarcelos, AnabelaLopes, David G.Canhão, HelenaBranco, JaimeMaria Rodrigues, Ana2022-02-23T23:17:44Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/133487eng2352-1872PURE: 41765276https://doi.org/10.1016/j.bonr.2021.101139info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:59:46Zoai:run.unl.pt:10362/133487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:30:43.202996Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Multimorbidity is associated with fragility fractures in women 50 years and older
A nationwide cross-sectional study
title Multimorbidity is associated with fragility fractures in women 50 years and older
spellingShingle Multimorbidity is associated with fragility fractures in women 50 years and older
Barcelos, Anabela
Fragility fractures
Multimorbidity
Osteoporosis
Women
Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
SDG 3 - Good Health and Well-being
title_short Multimorbidity is associated with fragility fractures in women 50 years and older
title_full Multimorbidity is associated with fragility fractures in women 50 years and older
title_fullStr Multimorbidity is associated with fragility fractures in women 50 years and older
title_full_unstemmed Multimorbidity is associated with fragility fractures in women 50 years and older
title_sort Multimorbidity is associated with fragility fractures in women 50 years and older
author Barcelos, Anabela
author_facet Barcelos, Anabela
Lopes, David G.
Canhão, Helena
Branco, Jaime
Maria Rodrigues, Ana
author_role author
author2 Lopes, David G.
Canhão, Helena
Branco, Jaime
Maria Rodrigues, Ana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Escola Nacional de Saúde Pública (ENSP)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Investigação em Saúde Pública (CISP/PHRC)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Estudos de Doenças Crónicas (CEDOC)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Barcelos, Anabela
Lopes, David G.
Canhão, Helena
Branco, Jaime
Maria Rodrigues, Ana
dc.subject.por.fl_str_mv Fragility fractures
Multimorbidity
Osteoporosis
Women
Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
SDG 3 - Good Health and Well-being
topic Fragility fractures
Multimorbidity
Osteoporosis
Women
Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
SDG 3 - Good Health and Well-being
description Funding Information: The study was supported by unrestricted grants from Direcção-Geral da Saúde , Fundação Calouste Gulbenkian , Fundação Champalimaud , Fundação AstraZeneca , Abbvie , Merck, Sharp & Dohme , Pfizer , Roche , Servier , Bial , D3A Medical Systems , Happybrands , Center de Medicina Laboratorial Germano de Sousa , Clínica Médica da Praia da Vitória , CAL-Clínica , Galp Energia , Açoreana Seguros , and individual rheumatologists .
publishDate 2021
dc.date.none.fl_str_mv 2021-12
2021-12-01T00:00:00Z
2022-02-23T23:17:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/133487
url http://hdl.handle.net/10362/133487
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2352-1872
PURE: 41765276
https://doi.org/10.1016/j.bonr.2021.101139
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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