Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles

Bibliographic Details
Main Author: Castanheira, Elisabete M. S.
Publication Date: 2006
Other Authors: Pinto, Ana M. R., Queiroz, Maria João R. P.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/5578
Summary: Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pKa = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.
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spelling Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesiclesBenzothienopyridopyrimidonepH probeLipid vesiclesScience & TechnologyFluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pKa = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.Fundação para a Ciência e a Tecnologia (FCT)SpringerUniversidade do MinhoCastanheira, Elisabete M. S.Pinto, Ana M. R.Queiroz, Maria João R. P.2006-032006-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/5578eng"Journal of fluorescence". ISSN 1053-0509. 16:2 (Mar. 2006) 251-257.1053-050910.1007/s10895-005-0050-z16575549The original publication is available at www.springerlink.cominfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:19:12Zoai:repositorium.sdum.uminho.pt:1822/5578Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:14:35.990692Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
spellingShingle Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
Castanheira, Elisabete M. S.
Benzothienopyridopyrimidone
pH probe
Lipid vesicles
Science & Technology
title_short Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_full Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_fullStr Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_full_unstemmed Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
title_sort Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
author Castanheira, Elisabete M. S.
author_facet Castanheira, Elisabete M. S.
Pinto, Ana M. R.
Queiroz, Maria João R. P.
author_role author
author2 Pinto, Ana M. R.
Queiroz, Maria João R. P.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Castanheira, Elisabete M. S.
Pinto, Ana M. R.
Queiroz, Maria João R. P.
dc.subject.por.fl_str_mv Benzothienopyridopyrimidone
pH probe
Lipid vesicles
Science & Technology
topic Benzothienopyridopyrimidone
pH probe
Lipid vesicles
Science & Technology
description Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pKa = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.
publishDate 2006
dc.date.none.fl_str_mv 2006-03
2006-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/5578
url http://hdl.handle.net/1822/5578
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Journal of fluorescence". ISSN 1053-0509. 16:2 (Mar. 2006) 251-257.
1053-0509
10.1007/s10895-005-0050-z
16575549
The original publication is available at www.springerlink.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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