Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review

Bibliographic Details
Main Author: Rodrigues, Tiago
Publication Date: 2021
Other Authors: Raposo, Sofia, Brito, Dulce, Lopes, Luis
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/49494
Summary: © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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spelling Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic reviewExercise testingHypertrophic cardiomyopathyPrognostic stratificationSystematic review© 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Background: Cardiopulmonary exercise test (CPET) is indicated as part of the assessment in hypertrophic cardiomyopathy (HCM) patients and stress echocardiography is often used to assess symptoms. However, the role of exercise testing for prognostic stratification in HCM is still not established. Aims: To systematically review the evidence on the role of exercise testing for prognostic stratification in hypertrophic cardiomyopathy. Methods: A systematic review was conducted for eligible publications, between 2010 and 2020, that included evaluation of outcomes and prognosis. In these studies, patients underwent exercise echocardiography and/or cardiopulmonary exercise testing, performed according to predefined protocols. Diverse parameters were assessed in order to determine which were relevant for the prognosis. Analyzed outcomes included death from any cause, sudden cardiac death (SCD) and equivalents, cardiovascular death, heart failure requiring hospitalization or progression to New York Heart Association classes III or IV, cardiac transplantation, non-sustained ventricular tachycardia, stroke, myocardial infarction and invasive septal reduction therapy. Results: Eighteen publications were included, corresponding to a total of 7525 patients. The mean follow-up period varied between 1 and 8 years. The main findings of these studies revealed that the major predictors of outcomes were abnormal heart rate recovery, abnormal blood pressure response exercise induced wall motion abnormalities, lower peak VO2, higher VE/VCO2, and pulmonary hypertension/exercise-induced pulmonary hypertension. Conclusion: Although most studies concluded that exercise test results are useful to determine prognosis in HCM, further investigation is needed regarding whether it adds independent value to the current risk stratification strategies.ElsevierRepositório da Universidade de LisboaRodrigues, TiagoRaposo, SofiaBrito, DulceLopes, Luis2021-09-09T14:38:30Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49494engInt J Cardiol. 2021 Sep 15;339:83-920167-527310.1016/j.ijcard.2021.06.0511874-1754info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:36:57Zoai:repositorio.ulisboa.pt:10451/49494Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:17:06.404127Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
title Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
spellingShingle Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
Rodrigues, Tiago
Exercise testing
Hypertrophic cardiomyopathy
Prognostic stratification
Systematic review
title_short Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
title_full Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
title_fullStr Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
title_full_unstemmed Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
title_sort Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review
author Rodrigues, Tiago
author_facet Rodrigues, Tiago
Raposo, Sofia
Brito, Dulce
Lopes, Luis
author_role author
author2 Raposo, Sofia
Brito, Dulce
Lopes, Luis
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodrigues, Tiago
Raposo, Sofia
Brito, Dulce
Lopes, Luis
dc.subject.por.fl_str_mv Exercise testing
Hypertrophic cardiomyopathy
Prognostic stratification
Systematic review
topic Exercise testing
Hypertrophic cardiomyopathy
Prognostic stratification
Systematic review
description © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-09-09T14:38:30Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49494
url http://hdl.handle.net/10451/49494
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Cardiol. 2021 Sep 15;339:83-92
0167-5273
10.1016/j.ijcard.2021.06.051
1874-1754
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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