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An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli

Bibliographic Details
Main Author: Moreira, Xavier
Publication Date: 2020
Other Authors: Santos, Patrícia, Faustino, M. Amparo F., Raposo, M. Manuela M., Costa, Susana P.G., Moura, Nuno M.M., Gomes, Ana T.P.C., Almeida, Adelaide, Neves, M.G.P.M.S.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10773/36755
Summary: New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI.
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spelling An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coliPorphyrinN-HeterocyclesPhotosensitizerAntimicrobial photodynamic therapyGram-negative E. coliNew porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI.Elsevier2023-03-30T15:20:17Z2020-07-01T00:00:00Z2020-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/36755eng0143-720810.1016/j.dyepig.2020.108330Moreira, XavierSantos, PatríciaFaustino, M. Amparo F.Raposo, M. Manuela M.Costa, Susana P.G.Moura, Nuno M.M.Gomes, Ana T.P.C.Almeida, AdelaideNeves, M.G.P.M.S.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-06T04:43:54Zoai:ria.ua.pt:10773/36755Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:18:14.783560Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
title An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
spellingShingle An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
Moreira, Xavier
Porphyrin
N-Heterocycles
Photosensitizer
Antimicrobial photodynamic therapy
Gram-negative E. coli
title_short An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
title_full An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
title_fullStr An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
title_full_unstemmed An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
title_sort An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli
author Moreira, Xavier
author_facet Moreira, Xavier
Santos, Patrícia
Faustino, M. Amparo F.
Raposo, M. Manuela M.
Costa, Susana P.G.
Moura, Nuno M.M.
Gomes, Ana T.P.C.
Almeida, Adelaide
Neves, M.G.P.M.S.
author_role author
author2 Santos, Patrícia
Faustino, M. Amparo F.
Raposo, M. Manuela M.
Costa, Susana P.G.
Moura, Nuno M.M.
Gomes, Ana T.P.C.
Almeida, Adelaide
Neves, M.G.P.M.S.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, Xavier
Santos, Patrícia
Faustino, M. Amparo F.
Raposo, M. Manuela M.
Costa, Susana P.G.
Moura, Nuno M.M.
Gomes, Ana T.P.C.
Almeida, Adelaide
Neves, M.G.P.M.S.
dc.subject.por.fl_str_mv Porphyrin
N-Heterocycles
Photosensitizer
Antimicrobial photodynamic therapy
Gram-negative E. coli
topic Porphyrin
N-Heterocycles
Photosensitizer
Antimicrobial photodynamic therapy
Gram-negative E. coli
description New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-01T00:00:00Z
2020-07
2023-03-30T15:20:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/36755
url http://hdl.handle.net/10773/36755
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0143-7208
10.1016/j.dyepig.2020.108330
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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